XIAP 抗体 (AA 15-244)
(1 reference)Quick Overview for XIAP 抗体 (AA 15-244) (ABIN4886770)
抗原
See all XIAP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 15-244
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原理
- Anti-XIAP Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-XIAP Antibody Picoband® (ABIN4886770). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human XIAP recombinant protein (Position: A15-V244). Human XIAP shares 89.4% and 90.7% amino acid (aa) sequence identity with mouse and rat XIAP, respectively.
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亚型
- IgG
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anti-X-Linked Inhibitor of Apoptosis (XIAP) (pSer87) antibody
XIAP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (C-Term) antibodyKO Validated XIAP 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 201-330) antibodyXIAP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-497) antibodyXIAP 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-497) antibodyXIAP 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-497) antibodyXIAP 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 51-150) antibodyXIAP 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 1F4 unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-268) antibodyXIAP 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4C12G10 unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-30) antibodyXIAP 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-200) antibodyXIAP 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Cummins, J. M., Kohli, M., Rago, C., Kinzler, K. W., Vogelstein, B., Bunz, F.X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.Cancer Res. 64: 3006-3008, 2004. 2. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., Reed, J. C.X-linked IAP is a inhibitor of cell-death proteases.Nature 388: 300-304, 1997. 3. Kim, J., Park, J., Choi, S., Chi, S.-G., Mowbray, A. L., Jo, H., Park, H.X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival.Circ. Res. 102: 896-904, 2008. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Gene transfection mediated by polyethyleneimine-polyethylene glycol nanocarrier prevents cisplatin-induced spiral ganglion cell damage." in: Neural regeneration research, Vol. 10, Issue 3, pp. 425-31, (2015) (PubMed).
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: "Gene transfection mediated by polyethyleneimine-polyethylene glycol nanocarrier prevents cisplatin-induced spiral ganglion cell damage." in: Neural regeneration research, Vol. 10, Issue 3, pp. 425-31, (2015) (PubMed).
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- XIAP (X-Linked Inhibitor of Apoptosis (XIAP))
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别名
- XIAP
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背景
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Synonyms: E3 ubiquitin-protein ligase XIAP,6.3.2.-,Baculoviral IAP repeat-containing protein 4,IAP-like protein,ILP,hILP,Inhibitor of apoptosis protein 3,IAP-3,hIAP-3,hIAP3,X-linked inhibitor of apoptosis protein,X-linked IAP,XIAP,API3, BIRC4, IAP3,
Tissue Specificity: Ubiquitous, except peripheral blood leukocytes.
Background: XIAP, also known as IAP3 or BIRC4, is a protein that stops apoptotic cell death. It is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants.
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分子量
- 55 kDa
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基因ID
- 331
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UniProt
- P98170
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis
抗原
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