GIP 抗体 (AA 52-93)
Quick Overview for GIP 抗体 (AA 52-93) (ABIN4886602)
抗原
See all GIP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 52-93
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原理
- Anti-GIP Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-GIP Antibody Picoband® (ABIN4886602). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human GIP recombinant protein (Position: Y52-Q93). Human GIP shares 92.9% and 95.2% amino acid (aa) sequence identity with mouse and rat GIP, respectively.
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亚型
- IgG
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anti-Gastric Inhibitory Polypeptide (GIP) (AA 22-153) antibody
GIP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gastric Inhibitory Polypeptide (GIP) antibodyGIP 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gastric Inhibitory Polypeptide (GIP) (AA 52-93) antibodyGIP 适用: 大鼠, 小鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Gastric Inhibitory Polypeptide (GIP) (AA 113-131) antibodyGIP 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gastric Inhibitory Polypeptide (GIP) (AA 22-153) antibodyGIP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gastric Inhibitory Polypeptide (GIP) antibodyGIP 适用: 人, 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gastric Inhibitory Polypeptide (GIP) antibodyGIP 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Gastric Inhibitory Polypeptide (GIP) antibodyGIP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Gastric Inhibitory Polypeptide (GIP) antibodyGIP 适用: 人 IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Gastric Inhibitory Polypeptide (GIP) antibodyGIP 适用: Various Species WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal A2 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Rat
1. Gaudin-Audrain C, Irwin N, Mansur S, Flatt PR, Thorens B, Baslé M, Chappard D, Mabilleau G (Mar 2013). "Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice". Bone 53 (1): 221-30. 2. Mieczkowska A, Irwin N, Flatt PR, Chappard D, Mabilleau G (Oct 2013). "Glucose-dependent insulinotropic polypeptide (GIP) receptor deletion leads to reduced bone strength and quality".Bone 56 (2): 337-42. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- GIP (Gastric Inhibitory Polypeptide (GIP))
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别名
- GIP
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背景
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Synonyms: Gastric inhibitory polypeptide,GIP,Glucose-dependent insulinotropic polypeptide,Incretin hormone,GIP,
Tissue Specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. .
Background: Gastric inhibitory polypeptide (GIP), also known as the glucose-dependent insulinotropic peptide, is an inhibiting hormone of the secretin family of hormones. GIP is thought to have significant effects on fatty acid metabolism through stimulation of lipoprotein lipase activity in adipocytes. Additionally, GIP release has been demonstrated in the ruminant animal and may play a role in nutrient partitioning in milk production (lipid metabolism). Recently, GIP appeared as a major player in bone remodelling. It was evidenced that genetic ablation of the GIP receptor in mice resulted in profound alterations of bone microarchitecture through modification of the adipokine network. Furthermore, the deficiency in GIP receptors has also been associated in mice with a dramatic decrease in bone quality and a subsequent increase in fracture risk.
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分子量
- 17 kDa
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基因ID
- 2695
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UniProt
- P09681
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途径
- Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Regulation of Lipid Metabolism by PPARalpha, Lipid Metabolism
抗原
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