CIITA 抗体 (AA 945-1130)
(1 reference)Quick Overview for CIITA 抗体 (AA 945-1130) (ABIN4886541)
抗原
See all CIITA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 945-1130
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原理
- Anti-CIITA Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-CIITA Antibody Picoband® (ABIN4886541). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CIITA recombinant protein (Position: E945-R1130). Human CIITA shares 84.4% amino acid (aa) sequence identity with mouse CIITA.
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亚型
- IgG
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anti-Class II, Major Histocompatibility Complex, Transactivator (CIITA) (Internal Region) antibody
CIITA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Class II, Major Histocompatibility Complex, Transactivator (CIITA) (C-Term) antibodyCIITA 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Class II, Major Histocompatibility Complex, Transactivator (CIITA) (AA 841-890) antibodyCIITA 适用: 小鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Class II, Major Histocompatibility Complex, Transactivator (CIITA) (C-Term) antibodyCIITA 适用: 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Class II, Major Histocompatibility Complex, Transactivator (CIITA) (AA 1-333) antibodyCIITA 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Class II, Major Histocompatibility Complex, Transactivator (CIITA) (AA 706-755) antibodyCIITA 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Raval A, Howcroft TK, Weissman JD, Kirshner S, Zhu XS, Yokoyama K, Ting J, Singer DS (Jan 2001). "Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250".Molecular Cell 7 (1): 105-15. 2. Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, McPherson A, Meissner B, Okoye UC, Diepstra A, van den Berg A, Sun M, Leung G, Jones SJ, Connors JM, Huntsman DG, Savage KJ, Rimsza LM, Horsman DE, Staudt LM, Steidl U, Marra MA, Gascoyne RD (Mar 2011). "MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers". Nature 471 (7338): 377-81. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation." in: Cell death & disease, Vol. 6, pp. e1859, (2016) (PubMed).
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: "Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation." in: Cell death & disease, Vol. 6, pp. e1859, (2016) (PubMed).
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- CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))
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别名
- CIITA
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背景
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Synonyms: MHC class II transactivator,CIITA,2.3.1.-,2.7.11.1,CIITA,MHC2TA,
Tissue Specificity: Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. .
Background: CIITA is a human gene which is mapped to 16p13. This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. Also, the protein binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.
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分子量
- 123 kDa
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基因ID
- 4261
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UniProt
- P33076
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途径
- Cancer Immune Checkpoints
抗原
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