Cofilin 2 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for Cofilin 2 抗体 (C-Term) (ABIN4886538)
抗原
See all Cofilin 2 (CFL2) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 121-153, C-Term
-
原理
- Anti-Cofilin 2/CFL2 Antibody
-
序列
- KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKL
-
交叉反应 (详细)
- No cross-reactivity with other proteins
-
产品特性
- Anti-Cofilin 2/CFL2 Antibody (ABIN4886538). Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Cofilin 2, identical to the related mouse sequence.
-
亚型
- IgG
-
-
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human -
说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- Cofilin 2 (CFL2)
-
别名
- CFL2
-
背景
-
Synonyms: Cofilin-2,Cofilin, muscle isoform,CFL2,
Tissue Specificity: Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
Background: Cofilin 2 (muscle), also known as CFL2, is a protein which in humans is encoded by the CFL2 gene. It is mapped to 14q12. This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. And this protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH -dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
-
分子量
- 26 kDa
-
基因ID
- 1073
-
UniProt
- Q9Y281
-
途径
- Caspase Cascade in Apoptosis
抗原
-