Complement Factor I 抗体 (AA 19-220)
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Quick Overview for Complement Factor I 抗体 (AA 19-220) (ABIN4886537)
抗原
See all Complement Factor I (CFI) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-220
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原理
- Anti-Factor I/CFI Antibody
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- coli-derived human Factor I recombinant protein (Position: K19-D220). Human Factor I shares 70.7%,71.2% amino acid (aa) sequence identity with mouse,rat Factor I,respectively.
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产品特性
- Anti-Factor I/CFI Antibody. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human Factor I recombinant protein (Position: K19-D220). Human Factor I shares 70.7% and 71.2% amino acid (aa) sequence identity with mouse and rat Factor I, respectively.
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亚型
- IgG
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anti-Complement Factor I (CFI) (AA 358-603) antibody
CFI 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor I (CFI) (AA 28-243) antibodyCFI 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor I (CFI) (AA 19-118) antibodyCFI 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-Complement Factor I (CFI) (AA 1-377) antibodyCFI 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Factor I (CFI) (Internal Region) antibodyCFI 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor I (CFI) (AA 239-316) antibodyCFI 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor I (CFI) (AA 340-583) antibodyCFI 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor I (CFI) (AA 1-377) antibodyCFI 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor I (CFI) (AA 19-118) antibodyCFI 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Factor I (CFI) (AA 145-194) antibodyCFI 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, 0.1-0.5 μg/mL, Human, RatImmunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human Immunocytochemistry, 0.5-1 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- Complement Factor I (CFI)
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别名
- CFI
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背景
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Background: Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.
Gene Full Name: complement factor I
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分子量
- 75 kDa, 45 kDa
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基因ID
- 3426
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UniProt
- P05156
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途径
- Complement System
抗原
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