AIRE 抗体 (AA 1-120)
Quick Overview for AIRE 抗体 (AA 1-120) (ABIN4886444)
抗原
See all AIRE 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-120
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原理
- Anti-AIRE Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-AIRE Antibody Picoband® (ABIN4886444). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human AIRE recombinant protein (Position: M1-K120). Human AIRE shares 87.2% amino acid (aa) sequence identity with mouse AIRE.
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亚型
- IgG
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anti-Autoimmune Regulator (AIRE) (C-Term) antibody
Verified AIRE 适用: 人 WB, ELISA, IF, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (AA 30-130) antibodyAIRE 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (N-Term) antibodyAIRE 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (Internal Region) antibodyVerified AIRE 适用: 人, Pig WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (Internal Region) antibodyAIRE 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (AA 39-108) antibodyAIRE 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (pSer156) antibodyAIRE 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (N-Term) antibodyAIRE 适用: 人, 小鼠, 大鼠, 犬, 马, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (AA 76-125) antibodyAIRE 适用: 人, 马, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (Internal Region) antibodyVerified AIRE 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
1. Lindmark E, Chen Y, Georgoudaki AM, Dudziak D, Lindh E, Adams WC, Loré K, Winqvist O, Chambers BJ, Karlsson MC, et al. (2013). "AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment.". Journal of Autoimmunity 42: 62-70. 2. Liston A, Lesage S, Wilson J, Peltonen L, Goodnow CC (April 2003). "Aire regulates negative selection of organ-specific T cells". Nat. Immunol. 4(4): 350-4. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- AIRE (Autoimmune Regulator (AIRE))
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别名
- AIRE
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背景
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Synonyms: Autoimmune regulator,Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein,APECED protein,AIRE,APECED,
Tissue Specificity: Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
Background: The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
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分子量
- 58-68 kDa
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基因ID
- 326
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UniProt
- O43918
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途径
- Chromatin Binding
抗原
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