BRISC and BRCA1 A Complex Member 1 (BABAM1) (Middle Region) 抗体
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Quick Overview for BRISC and BRCA1 A Complex Member 1 (BABAM1) (Middle Region) 抗体 (ABIN453692)
抗原
See all BRISC and BRCA1 A Complex Member 1 (BABAM1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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特异性
- This antibody recognizes MERIT40/HSPC142 (Center).
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纯化方法
- Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- KLH conjugated synthetic peptide selected from the Center region of Human HSPC142
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anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 36-85) antibody
BABAM1 适用: 人, 小鼠, 犬, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-329) antibodyBABAM1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 116-143) antibodyBABAM1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20468 unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 9-37), (N-Term) antibodyBABAM1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20467 unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (N-Term) antibodyBABAM1 适用: 人, 小鼠, 犬, 豚鼠, 马, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/1,000. Western blotting: 1/50-1/100. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- BRISC and BRCA1 A Complex Member 1 (BABAM1)
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别名
- MERIT40
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背景
- Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.Synonyms: BRCA1-A complex subunit MERIT40, C19orf62, HSPC142, Mediator of RAP80 interactions and targeting subunit of 40 kDa, NBA1, New component of the BRCA1-A complex
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基因ID
- 29086
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NCBI登录号
- NP_001028721
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UniProt
- Q9NWV8
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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