DERL1 抗体 (C-Term)
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Quick Overview for DERL1 抗体 (C-Term) (ABIN453618)
抗原
See all DERL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 222-251, C-Term
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特异性
- This antibody recognizes Human and Mouse Derlin-1 at C-term. Other species not tested.
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纯化方法
- Protein A column, followed by peptide affinity purification
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免疫原
- KLH conjugated synthetic peptide between 222~251 amino acids from the C-term region of Human Derlin-1 Genename: DERL1
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anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 224-251), (C-Term) antibody
DERL1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22770 unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 111-220) antibodyDERL1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 224-251) antibodyDERL1 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 200-251), (C-Term) antibodyDERL1 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
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别名
- Derlin-1
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背景
- Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.Synonyms: DER1, DERL1, DERtrin-1, Degradation in endoplasmic reticulum protein 1, Der1-like protein 1
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基因ID
- 79139
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NCBI登录号
- NP_001128143
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UniProt
- Q9BUN8
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途径
- ER-Nucleus Signaling
抗原
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