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SKP2 抗体 (Middle Region)

The 兔 多克隆 anti-SKP2 antibody (ABIN453378) specifically detects SKP2 in WB 和 EIA. The antibody is reactive with 人 samples.
产品编号 ABIN453378
发货至: 中国
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Quick Overview for SKP2 抗体 (Middle Region) (ABIN453378)

抗原

See all SKP2 抗体
SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))

适用

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宿主

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克隆类型

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多克隆

标记

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This SKP2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Enzyme Immunoassay (EIA)
  • 抗原表位

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    Middle Region

    特异性

    This antibody reacts to SKP2.

    纯化方法

    Saturated Ammonium Sulfate (SAS) precipitation

    免疫原

    KLH conjugated synthetic peptide selected from the Center region of human SKP2
  • 应用备注

    ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.25 mg/mL

    缓冲液

    PBS with 0.09 % (W/V) sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))

    别名

    SKP2 / FBXL1

    背景

    SKP2 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class, in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas.Synonyms: Cyclin-A/CDK2-associated protein p45, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2

    基因ID

    6502

    NCBI登录号

    NP_005974

    UniProt

    Q13309

    途径

    Mitotic G1-G1/S Phases
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