Quick Overview for PML 抗体 (ABIN452172)
抗原
See all PML 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody recognizes normal PML proteins of lower Molecular Weight, and also recognizes the High Molecular Weight PML/RAR-alpha Chimeric protein in promyelocytic leukemia patients.
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交叉反应 （详细）
- Species reactivity (tested):Human.
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产品特性
- Synonyms: RING finger protein 71, MYL, TRIM19, Probable transcription factor PML, Tripartitemotif-containing protein 19
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纯化方法
- Affinity Chromatography on Protein G.
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免疫原
- Recombinant partial Human PML.
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亚型
- IgG1
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anti-Promyelocytic Leukemia (PML) (AA 411-510) antibody
PML 适用: 人 WB, IF, ELISA, PLA 宿主: 小鼠 Monoclonal 1D12 unconjugated
anti-Promyelocytic Leukemia (PML) (N-Term) antibodyPML 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 470-499), (Sumoylation Site) antibodyPML 适用: 人 WB, IHC, IF, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 300-600) antibodyPML 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (C-Term) antibodyPML 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 犬, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 411-510) antibodyPML 适用: 人 WB, IF, ELISA 宿主: 小鼠 Monoclonal 2B10 unconjugated
anti-Promyelocytic Leukemia (PML) (C-Term) antibodyPML 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 470-499), (Sumoylation Site) antibodyPML 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB2570 unconjugated
anti-Promyelocytic Leukemia (PML) (N-Term) antibodyPML 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 588-637) antibodyPML 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: Use PML antibody at 1/2,000 dilution to differentiate normal PML andChimeric PML/RAR alpha molecules based on their molecular weight.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore by adding appropriate volume of distilled water to reach a final antibody concentration of 1.0 mg/mL.
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缓冲液
- 0.01 M PBS, pH 7.4 without preservatives.
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储存液
- Without preservative
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
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Store the antibody (in aliquots) at -20 °C. After reconstitution, aliquot and store at -20 °C.
Shelf life: one year from despatch. -
有效期
- 12 months
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- PML (Promyelocytic Leukemia (PML))
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别名
- PML / RNF71
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背景
- PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals.Synonyms: MYL, Probable transcription factor PML, RING finger protein 71, TRIM19, Tripartite motif-containing protein 19
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基因ID
- 5371
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UniProt
- P29590
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途径
- p53 Pathway, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
抗原
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