CDK7 抗体 (C-Term)
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Quick Overview for CDK7 抗体 (C-Term) (ABIN452138)
抗原
See all CDK7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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特异性
- Mo-1.1 recognizes the key cell cycle regulator cdk7, which is essential to activate the cdk2 kinase in G1 phase and the cdc2 kinase in G2/M phase.
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产品特性
- Synonyms: CAK1, P39 Mo15, STK1, CDK-activating kinase, Cell division protein kinase 7, TFIIH basaltranscription factor complex kinase subunit, 39 kDa protein kinase
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纯化方法
- Protein A affinity chromatography
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免疫原
- Recombinant C-terminal 221 aa fragment of human wild-type cdk7/CAK (cyclin activatingkinase)
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亚型
- IgG2b
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应用备注
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Immunohistochemistry of frozen sections: 1/10 - 1/20, 1h at RT. Immunofluorescence. Immunoprecipitation of active kinase complex. Cell sorting (FACS analysis). Immunoblotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore in 1 mL dist. water (final solution contains 0.09 % NaN3, 0.5 % BSA in PBS buffer, pH 7.4).
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储存条件
- 4 °C/-20 °C
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储存方法
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Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- CDK7 (Cyclin-Dependent Kinase 7 (CDK7))
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别名
- CDK7
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背景
- Cdk7 is a member of the cyclin dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. Cdk7 forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.Synonyms: 39 kDa protein kinase, CAK1, CDK-activating kinase, Cell division protein kinase 7, P39 Mo15, STK1, TFIIH basal transcription factor complex kinase subunit
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基因ID
- 1022
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UniProt
- P50613
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途径
- Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase
抗原
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