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Calnexin 抗体 (Internal Region)

Name: Calnexin 抗体 (Internal Region)
SKU: ABIN401659
Availability: OutOfStock

CANX 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig WB, IHC (p), EIA 宿主: 山羊 Polyclonal unconjugated

Image no. 2 for anti-Calnexin (CANX) (Internal Region) antibody (ABIN401659) (Calnexin 抗体 (Internal Region))

Image no. 1 for anti-Calnexin (CANX) (Internal Region) antibody (ABIN401659) (Calnexin 抗体 (Internal Region))

Image no. 3 for anti-Calnexin (CANX) (Internal Region) antibody (ABIN401659) (Calnexin 抗体 (Internal Region))

3 images

(2 references)

产品编号 ABIN401659

发货至: 中国

Datasheet as PDF

抗原 See all Calnexin (CANX) 抗体

Calnexin (CANX)
抗原表位
49

17

14

6

5

5

5

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region
适用
117

73

72

48

34

31

31

29

29

26

25

25

22

21

20

6

3

3

2

2

2

1

1

1

1

1

1

1

1
人, 小鼠, 大鼠, 犬, Cow, Pig
宿主
117

23

7
山羊
Compatible Secondaries
克隆类型
114

34
多克隆
标记
71

8

7

5

5

4

4

4

3

3

3

3

3

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Calnexin antibody is un-conjugated
应用范围
123

79

57

56

39

28

27

26

21

14

13

9

8

4

3

3

2

2

2

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

序列

c-SKTPELNLDQ FHDKT

特异性

This antibody recognizes Calnexin.

交叉反应（详细）

Species reactivity (expected):Rat, Canine, Pig, Bovine.
Species reactivity (tested):Human, Mouse.

纯化方法

Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

免疫原

Peptide with sequence from the internal region (near N-Terminus) of the protein sequence . Genename: CANX

Top Product

Discover our top product CANX Primary Antibody
anti-Calnexin (CANX) (C-Term) antibody
CANX 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 豚鼠, Pig, 猴, 绵羊, Hamster, 小鸡, Avian, 马, 山羊, Cat, 驴 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated

anti-Calnexin (CANX) (C-Term) antibody
CANX 适用: 犬 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calnexin (CANX) (Internal Region) antibody
CANX 适用: 人, 小鼠, 大鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Calnexin (CANX) (AA 263-482) antibody
CANX 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calnexin (CANX) (AA 1-300), (N-Term) antibody
CANX 适用: 人 WB, IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal CANX-1541 unconjugated

anti-Calnexin (CANX) (AA 504-592) antibody
CANX 适用: 人 WB, IF, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 1D4 unconjugated

anti-Calnexin (CANX) (AA 239-461) antibody
CANX 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calnexin (CANX) (AA 239-461) antibody
CANX 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C3 unconjugated

anti-Calnexin (CANX) (AA 1-300), (N-Term) antibody
CANX 适用: 人 WB, IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal CANX-1543 unconjugated

anti-Calnexin (CANX) (C-Term) antibody
CANX 适用: 犬 WB, IHC, IF, IP, FACS, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Peptide ELISA: 1/32000. Western blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

0.5 mg/mL

缓冲液

Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Ho, Chang, Su, Chang, Hu, Jou, Wang: "Inhibition of matrix metalloproteinase activity reverses corneal endothelial-mesenchymal transition." in: The American journal of pathology, Vol. 185, Issue 8, pp. 2158-67, (2016) (PubMed).

Cordek, Croom-Perez, Hwang, Hargittai, Subba-Reddy, Han, Lodeiro, Ning, McCrory, Arnold, Koc, Lindenbach, Showalter, Cameron: "Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein." in: The Journal of biological chemistry, Vol. 289, Issue 35, pp. 24397-416, (2015) (PubMed).
抗原

Calnexin (CANX)

别名

Calnexin (CANX 产品)

别名

CNX antibody, IP90 antibody, P90 antibody, 1110069N15Rik antibody, AI988026 antibody, Cnx antibody, D11Ertd153e antibody, canx antibody, clgn antibody, clnx antibody, cnx antibody, PP90 antibody, zgc:63524 antibody, wu:fe06b12 antibody, CANX antibody, calnexin antibody, CalNeXin antibody, calnexin L homeolog antibody, CANX antibody, Canx antibody, cnx-1 antibody, canx.L antibody, canx antibody, LOC100283947 antibody

背景

Calnexin, also referred to as IP90, p88 and p90, is an ~90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatability complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP 78 and GRP 94 and protein disulfide isomerase. Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention. Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids). These features distinguish calnexin from soluble ER chaperones that cannot interact with the transmembrane and cytosolic domains of integral membrane proteins. The amino acid sequence of calnexin is highly conserved among species, and shares regions of high sequence homology with calreticulin.Synonyms: CANX, ER Marker, IP90, Major histocompatibility complex class I antigen-binding protein p88, p90

基因ID

821

NCBI登录号

NP_001737

UniProt

P27824

途径

MAPK Pathway, Thyroid Hormone Synthesis