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Calnexin 抗体 (Internal Region)

This 山羊 多克隆 antibody specifically detects Calnexin in WB, IHC (p) 和 EIA. It exhibits reactivity toward 人, 小鼠, 大鼠, 犬, Cow 和 Pig. It has been mentioned in 2+ publications
Pubmed (2 references)
产品编号 ABIN401659
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Calnexin 抗体 (Internal Region) (ABIN401659)

抗原

See all Calnexin (CANX) 抗体
Calnexin (CANX)

适用

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人, 小鼠, 大鼠, 犬, Cow, Pig

宿主

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山羊

克隆类型

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多克隆

标记

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This Calnexin antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Discover our top product CANX Primary Antibody

  • 抗原表位

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    Internal Region

    序列

    c-SKTPELNLDQ FHDKT

    特异性

    This antibody recognizes Calnexin.

    交叉反应 （详细）

    Species reactivity (expected):Rat, Canine, Pig, Bovine.
    Species reactivity (tested):Human, Mouse.

    纯化方法

    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

    免疫原

    Peptide with sequence from the internal region (near N-Terminus) of the protein sequence . Genename: CANX
  • anti-Calnexin (CANX) (C-Term) antibody
    anti-Calnexin (CANX) (C-Term) antibody

    CANX 适用: 犬 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

    anti-Calnexin (CANX) (Internal Region) antibody
    anti-Calnexin (CANX) (Internal Region) antibody

    CANX 适用: 人, 小鼠, 大鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

    anti-Calnexin (CANX) (C-Term) antibody
    anti-Calnexin (CANX) (C-Term) antibody

    CANX 适用: 人, 小鼠, 大鼠, 犬, Cow, 猴, 兔, 豚鼠, Pig, Hamster, 绵羊, 小鸡, Avian, 马, 山羊, Cat, 驴 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated

    anti-Calnexin (CANX) (AA 263-482) antibody
    anti-Calnexin (CANX) (AA 263-482) antibody

    CANX 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

    anti-Calnexin (CANX) (AA 504-592) antibody
    anti-Calnexin (CANX) (AA 504-592) antibody

    CANX 适用: 人 WB, IF, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 1D4 unconjugated

    anti-Calnexin (CANX) (AA 1-300), (N-Term) antibody
    anti-Calnexin (CANX) (AA 1-300), (N-Term) antibody

    CANX 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal CANX-1541 unconjugated

    anti-Calnexin (CANX) (C-Term) antibody (Atto 390)
    anti-Calnexin (CANX) (C-Term) antibody (Atto 390)

    CANX 适用: 犬 WB, IHC, IF, ICC, IP, FACS 宿主: 兔 Polyclonal Atto 390

    anti-Calnexin (CANX) (C-Term) antibody (Atto 488)
    anti-Calnexin (CANX) (C-Term) antibody (Atto 488)

    CANX 适用: 犬 WB, IHC, IF, ICC, IP, FACS 宿主: 兔 Polyclonal Atto 488

    anti-Calnexin (CANX) (C-Term) antibody (Atto 594)
    anti-Calnexin (CANX) (C-Term) antibody (Atto 594)

    CANX 适用: 犬 WB, IHC, IF, ICC, IP, FACS 宿主: 兔 Polyclonal Atto 594

    anti-Calnexin (CANX) (C-Term) antibody (APC)
    anti-Calnexin (CANX) (C-Term) antibody (APC)

    CANX 适用: 犬 WB, IHC, IF, ICC, IP, FACS 宿主: 兔 Polyclonal APC

  • 应用备注

    Peptide ELISA: 1/32000. Western blot: 0.3 - 1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用

  • 浓度

    0.5 mg/mL

    缓冲液

    Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Ho, Chang, Su, Chang, Hu, Jou, Wang: "Inhibition of matrix metalloproteinase activity reverses corneal endothelial-mesenchymal transition." in: The American journal of pathology, Vol. 185, Issue 8, pp. 2158-67, (2016) (PubMed).

    Cordek, Croom-Perez, Hwang, Hargittai, Subba-Reddy, Han, Lodeiro, Ning, McCrory, Arnold, Koc, Lindenbach, Showalter, Cameron: "Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein." in: The Journal of biological chemistry, Vol. 289, Issue 35, pp. 24397-416, (2015) (PubMed).

  • 抗原

    Calnexin (CANX)

    别名

    Calnexin

    背景

    Calnexin, also referred to as IP90, p88 and p90, is an ~90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatability complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP 78 and GRP 94 and protein disulfide isomerase. Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention. Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids). These features distinguish calnexin from soluble ER chaperones that cannot interact with the transmembrane and cytosolic domains of integral membrane proteins. The amino acid sequence of calnexin is highly conserved among species, and shares regions of high sequence homology with calreticulin.Synonyms: CANX, ER Marker, IP90, Major histocompatibility complex class I antigen-binding protein p88, p90

    基因ID

    821

    NCBI登录号

    NP_001737

    UniProt

    P27824

    途径

    MAPK Pathway, Thyroid Hormone Synthesis
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