Paxillin 抗体 (Tyr88)
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Quick Overview for Paxillin 抗体 (Tyr88) (ABIN401644)
抗原
See all Paxillin (PXN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Tyr88
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特异性
- Paxillin Antibody detects endogenous levels of total Paxillin protein.
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纯化方法
- Affinity chromatography
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免疫原
- Synthesized non-phosphopeptide derived from human Paxillin around the phosphorylation site of tyrosine 88 (P-V-YP-G-S).
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应用备注
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Western Blot: 1/500 - 1/1000. Immunofluorescence: 1/100 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- Paxillin (PXN)
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别名
- Paxillin / PXN
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背景
- Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).Synonyms: FLJ16691
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基因ID
- 5829
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NCBI登录号
- NP_001074324
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UniProt
- P49023
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途径
- MAPK Pathway, EGFR Signaling Pathway, Response to Growth Hormone Stimulus, Cell-Cell Junction Organization, Maintenance of Protein Location, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
抗原
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