PRDM1 抗体 (C-Term)
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Quick Overview for PRDM1 抗体 (C-Term) (ABIN401477)
抗原
See all PRDM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody is directed against BLIMP1 protein.
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交叉反应 (详细)
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Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Synthetic peptide corresponding to a region near the C-terminus of human, mouse, and rat PRDM1/BLIMP1
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亚型
- IgG
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应用备注
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ELISA: 1/65,000 - 1/80,000. Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.15 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))
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别名
- PRDM1 / BLIMP1
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背景
- PRDM1/Blimp1 (PR domain zinc finger protein 1, PR domain-containing protein 1, Beta-interferon gene positive regulatory domain I-binding factor, BLIMP-1, Positive regulatory domain I-binding factor 1, PRDIbinding factor 1, or PRDI-BF1, or Betalymphocyte-induced maturation protein 1) is one of several transcription factors which drives the maturation of B-lymphocytes into Ig secreting cells. In the nucleus, PRDM1/BLIMP1 functions as a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Transcription of the PRDM1 gene is increased upon virus induction. PRDM1/Blimp1 also interacts with PRMT5. Two alternatively spliced transcript variants that encode different isoforms have been reported.Synonyms: BLIMP-1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain zinc finger protein 1, PR domain-containing protein 1, PRDI-BF1, PRDI-binding factor 1, Positive regulatory domain I-binding factor 1
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基因ID
- 639
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NCBI登录号
- NP_001189
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UniProt
- O75626
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途径
- Regulation of Muscle Cell Differentiation
抗原
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