CDK9 抗体 (pThr29)
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- 抗原 See all CDK9 抗体
- CDK9 (Cyclin-Dependent Kinase 9 (CDK9))
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抗原表位
- pThr29
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CDK9 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)
- 特异性
- This antibody is specific for CDK9 protein phosphorylated at T29. Expect a band approximately 42 kDa in size corresponding to phosphorylated CDK9 protein by Western blotting in the appropriate cell lysate or extract.
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity Chromatography
- 免疫原
- Synthetic peptide corresponding to residues surrounding Thr 29 in the Human CDK9 protein.
- 亚型
- IgG
- Top Product
- Discover our top product CDK9 Primary Antibody
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anti-Cyclin-Dependent Kinase 9 (CDK9) antibody
CDK9 适用: 人 WB, IHC, IP, IF, ChIP-seq 宿主: 兔 Monoclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 153-372) antibodyCDK9 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) antibodyCDK9 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 1B5A7 unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 271-372) antibodyCDK9 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D7 unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (Internal Region) antibodyCDK9 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 153-372) antibodyCDK9 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) antibodyCDK9 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 104-315) antibodyCDK9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 153-372) antibodyCDK9 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 141-372) antibodyCDK9 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- ELISA: 1/5,000-1/24,000. Western Blot: 1/200-1/2,000. Immunoprecipitation: 1/100.
- 限制
- 仅限研究用
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- 浓度
- 1.3 mg/mL (by UV absorbance at 280 nm)
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Store the antibody (in aliquots) at-20 °C.
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- 抗原
- CDK9 (Cyclin-Dependent Kinase 9 (CDK9))
- 别名
- CDK9 (CDK9 产品)
- 别名
- C-2k antibody, CDC2L4 antibody, CTK1 antibody, PITALRE antibody, TAK antibody, wu:fb22e09 antibody, wu:fc06c02 antibody, c-2k antibody, cdc2l4 antibody, cdk9 antibody, ctk1 antibody, pitalre antibody, tak antibody, CDK9 antibody, CG5179 antibody, Dmel\\CG5179 antibody, P-TEF antibody, P-TEFb antibody, PTefb antibody, cyclin dependent kinase 9 antibody, cyclin-dependent kinase 9 (CDC2-related kinase) antibody, cyclin-dependent kinase 9 L homeolog antibody, cyclin-dependent kinase 9 antibody, Cyclin-dependent kinase 9 antibody, cyclin-dependent kinase 9 S homeolog antibody, CDK9 antibody, cdk9 antibody, cdk9.L antibody, Cdk9 antibody, cdk9.S antibody
- 背景
- CDK9 (PITALRE) (also known as cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, C-2K and Cell division cycle 2-like protein kinase 4) is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2 and are known as important cell cycle regulators. CDK9 (PITALRE) interacts with a conserved domain in the TRAF-C region of the tumor necrosis factor signal transducer TRAF2. This kinase was also found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase IIdirected transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with, and is regulated by, its regulatory subunit, cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggests a possible involvement of this protein in AIDS. Tat stimulates human HIV-1 viral transcription elongation. This suggests that cyclin T1/CDK9(PITALRE) is one of the HIV-1 required host cellular cofactors generated during T cell activation. Cyclin T1/CDK9(PITALRE) has been shown to interact with Tat to restore Tat activation in HeLa nuclear extracts depleted of P-TEFb. CDK9(PITALRE) activity and cyclin T1 are essential for activation of viral transcription when tethered to the heterologous Rev response element RNA via the regulator of expression of virion Rev. CDK9 (PITALRE) is a ubiquitously expressed nuclear protein. CDK9 kinase activity is regulated by autophosphoryaltion of CDK9 at T29 and T186. T29 phosphorylation is uniquely induced by the HTLV-1 viral oncoprotein Tax.Synonyms: CDC2L4, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Cyclin-dependent kinase 9, PITALRE, Serine/threonine-protein kinase PITALRE
- 基因ID
- 1025
- NCBI登录号
- NP_001252
- UniProt
- P50750
- 途径
- Cell Division Cycle
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