HDAC1 抗体 (AA 466-482)
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Quick Overview for HDAC1 抗体 (AA 466-482) (ABIN401309)
抗原
See all HDAC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 466-482
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特异性
- This antibody is directed against HDAC-1 protein.
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交叉反应 (详细)
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Species reactivity (expected):Mouse, Rat, Chimpanzee, Bovine, Chicken.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Synthetic peptide corresponding to amino acids 466-482 of Human HDAC-1
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亚型
- IgG
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应用备注
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Western Blot: 1/1,000 - 1/5,000. ELISA: 1/10,000 - 1/50,000. Immunohistochemistry: 1/200 - 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.33 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- HDAC1 (Histone Deacetylase 1 (HDAC1))
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别名
- HDAC1
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背景
- HDAC1 (also known as HD1, histone deacetylase 1, RPD3, RPD3L1) belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.Synonyms: HD1, Histone deacetylase 1, RPD3L1
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基因ID
- 3065
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NCBI登录号
- NP_004955
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UniProt
- Q13547
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途径
- Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis
抗原
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