PARK7/DJ1 抗体 (AA 177-189)
Quick Overview for PARK7/DJ1 抗体 (AA 177-189) (ABIN401278)
抗原
See all PARK7/DJ1 (PARK7) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 177-189
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特异性
- Thisa ntibody is specific for PARK7.
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交叉反应 （详细）
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Species reactivity (expected):Chimpanzee, African green monkey, zebrafish and mutant/variant forms of human DJ-1 protein (100 %).. Cross reactivity with frog, mouse, rat, dog, chicken, Japanese rice fish and Atlantic salmon may also cross react as the sequence varies by only one amino acid residue as indicated by BLAST analysis.
Species reactivity (tested):Human. -
纯化方法
- Immunoaffinity chromatography
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免疫原
- Synthetic peptide corresponding aa 177-189 of Human PARK7 protein
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亚型
- IgG
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anti-Parkinson Protein 7 (PARK7) (AA 1-189) antibody
PARK7 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (C-Term) antibodyVerified PARK7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 101-189) antibodyPARK7 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (C-Term) antibodyPARK7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 2-189) antibodyPARK7 适用: 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 1-188) antibodyPARK7 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 1-189) antibodyPARK7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 2-189) antibodyPARK7 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 1-189) antibodyPARK7 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 130-164), (C-Term) antibodyPARK7 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB49681 unconjugated
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应用备注
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ELISA: 1: 10,000 - 1: 50,000. Immunohistochemistry on paraffin sections: 2 μg/mL - 5 μg/mL. Western blot: 1: 500 - 1: 2,000 (Expect a band approximately 28 kDa in size correspondingto PARK7 in the appropriate cell lysate or extract).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.3 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
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- PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
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别名
- DJ-1 / PARK7
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背景
- The product of the PARK7 gene, known as PARK7, Parkinson disease (autosomal recessive, early onset) 7, DJ-1 mutant, and DJ-1 oncogene product, functions as a positive regulator of androgen receptor-dependent transcription. PARK7 may also function as a redoxsensitive chaperone and as a sensor for oxidative stress and also has been reported to prevent aggregation of SNCA. PARK7 protects neurons against oxidative stress and cell death and plays a role in fertilization. While PARK7 has no proteolytic activity, it does have a weak transforming activity. PARK7 forms a homodimer and binds to DJBP and PIAS2. PARK7 is part of a ternary complex containing PARK7, DJBP and AR and shows both a nuclear and cytoplasmic localization. In some cells, PARK7 is associated with mitochondria, particularly after oxidative stress. This protein is highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart tissue, and is expressed at lower levels in placenta and brain. PARK7 is detected in tau inclusions in brains from neurodegenerative disease patients, in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, response to treatment with levodopa, the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins) in surviving neurons.Synonyms: Oncogene DJ1, Parkinson disease protein 7
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基因ID
- 11315
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NCBI登录号
- NP_001116849
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UniProt
- Q99497
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
抗原
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