SIK2 抗体
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北京 101111
Quick Overview for SIK2 抗体 (ABIN400680)
抗原
See all SIK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
- Synonyms: SIK-2, SNF1LK2, QIK, Serine/threonine-protein kinase SIK2, Salt-inducible protein kinase 2,Serine/threonine-protein kinase SNF1-like kinase 2, Qin-induced kinase
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纯化方法
- Affinity Chromatography.
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免疫原
- Recombinant Human SIK2.
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亚型
- IgG1
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应用备注
- Western blot. Immunoprecipitation. Immunofluorescence. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.2 containing 0.09% Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
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有效期
- 12 months
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- SIK2 (Salt-Inducible Kinase 2 (SIK2))
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别名
- SIK2
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背景
- Snf1lk2 belongs to the Ser/Thr protein kinase family, AMPK subfamily. It has one proteinkinase domain and one UBA domain. Snf1lk2 requires magnesium as a cofactor andphosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes. This potentiallymodulates the efficiency of insulin signal transduction. It also inhibits CREB activity byphosphorylating and repressing the CREB-specific coactivators, CRTC1-3. Snf1lk2 isactivated by phosphorylation on Thr-175 by STK11 in complex with STE20-relatedadapter-alpha (STRAD alpha) pseudo kinase and CAB39.
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UniProt
- Q9H0K1
抗原
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