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DUSP10 抗体 (N-Term)

This anti-DUSP10 antibody is a 兔 多克隆 antibody detecting DUSP10 in WB 和 IHC (p). Suitable for 人 和 小鼠.
产品编号 ABIN392871
发货至: 中国

Quick Overview for DUSP10 抗体 (N-Term) (ABIN392871)

抗原

See all DUSP10 抗体
DUSP10 (Dual Specificity Phosphatase 10 (DUSP10))

适用

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  • 1
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人, 小鼠

宿主

  • 48
  • 3
  • 1

克隆类型

  • 50
  • 2
多克隆

标记

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  • 1
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This DUSP10 antibody is un-conjugated

应用范围

  • 45
  • 23
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  • 6
  • 3
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  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB5879
  • 抗原表位

    • 15
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
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    • 1
    AA 1-30, N-Term

    预测反应

    B

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This DUSP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP10.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • 抗原

    DUSP10 (Dual Specificity Phosphatase 10 (DUSP10))

    别名

    DUSP10

    背景

    Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique, it is evenly distributed in both the cytoplasm and the nucleus. The protein is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli.

    分子量

    52642

    基因ID

    11221

    NCBI登录号

    NP_009138, NP_653329, NP_653330

    UniProt

    Q9Y6W6
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