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Hexokinase 1 抗体 (N-Term)

This anti-Hexokinase 1 antibody is a 兔 多克隆 antibody detecting Hexokinase 1 in WB 和 IHC (p). Suitable for 人 和 大鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN392759
发货至: 中国

Quick Overview for Hexokinase 1 抗体 (N-Term) (ABIN392759)

抗原

See all Hexokinase 1 (HK1) 抗体
Hexokinase 1 (HK1)

适用

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人, 大鼠

宿主

  • 116
  • 17

克隆类型

  • 107
  • 26
多克隆

标记

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This Hexokinase 1 antibody is un-conjugated

应用范围

  • 108
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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB3921-RB3922
  • 抗原表位

    • 8
    • 8
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    • 7
    • 7
    • 4
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    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 78-108, N-Term

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This HK1 (Hexokinase) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-108 amino acids from the N-terminal region of human HK1 (Hexokinase).

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:2000. WB: 1:1000. WB: 1:1000. IHC-P-Leica: 1:500

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Lynn, Wang, Markesbery, Lovell: "Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease." in: Journal of Alzheimer's disease : JAD, Vol. 19, Issue 1, pp. 325-39, (2010) (PubMed).

  • 抗原

    Hexokinase 1 (HK1)

    别名

    HK1 (Hexokinase)

    背景

    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus, the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.

    分子量

    102486

    基因ID

    3098

    NCBI登录号

    NP_000179, NP_277031, NP_277032, NP_277033, NP_277035

    UniProt

    P19367

    途径

    Carbohydrate Homeostasis, Warburg Effect
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