TRPM7 抗体 (C-Term)
Quick Overview for TRPM7 抗体 (C-Term) (ABIN2837991)
抗原
See all TRPM7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1821-1850, C-Term
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预测反应
- Rat
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This TRPM7 (CHAK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1821-1850 amino acids from the C-terminal region of human TRPM7 (CHAK1).
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels." in: The Journal of biological chemistry, Vol. 285, Issue 10, pp. 7430-9, (2010) (PubMed).
: "Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytes." in: Molecular and cellular biochemistry, Vol. 321, Issue 1-2, pp. 135-43, (2009) (PubMed).
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: "Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels." in: The Journal of biological chemistry, Vol. 285, Issue 10, pp. 7430-9, (2010) (PubMed).
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- TRPM7 (Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7))
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别名
- TRPM7 (CHAK1)
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背景
- TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]
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分子量
- 212697
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基因ID
- 54822
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NCBI登录号
- NP_060142
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UniProt
- Q96QT4
抗原
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