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ACVRL1 抗体 (N-Term)

ACVRL1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB03736 unconjugated
产品编号 ABIN392241
发货至: 中国
  • 抗原 See all ACVRL1 抗体
    ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))
    抗原表位
    • 8
    • 8
    • 6
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 38-68, N-Term
    适用
    • 60
    • 28
    • 17
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 54
    • 5
    • 1
    • 1
    克隆类型
    • 53
    • 7
    多克隆
    标记
    • 39
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ACVRL1 antibody is un-conjugated
    应用范围
    • 50
    • 32
    • 30
    • 12
    • 10
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-68 amino acids from the N-terminal region of human ACVRL1.
    克隆位点
    RB03736
    亚型
    Ig Fraction
  • 应用备注
    WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Muñoz-Félix, Cuesta, Perretta-Tejedor, Subileau, López-Hernández, López-Novoa, Martínez-Salgado: "Identification of bone morphogenetic protein 9 (BMP9) as a novel profibrotic factor in vitro." in: Cellular signalling, Vol. 28, Issue 9, pp. 1252-61, (2017) (PubMed).

    Antonov, Antonova, Fujii, ten Dijke, Handa, Catravas, Verin: "Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90." in: Journal of cellular physiology, Vol. 227, Issue 2, pp. 759-71, (2011) (PubMed).

    Finnson, Parker, ten Dijke, Thorikay, Philip: "ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 23, Issue 6, pp. 896-906, (2008) (PubMed).

    Yu, Pisitkun, Wang, Shen, Knepper: "LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 11, pp. 2131-45, (2006) (PubMed).

  • 抗原
    ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))
    别名
    ACVRL1 (ACVRL1 产品)
    别名
    ACVRL1 antibody, vgb antibody, alk1 antibody, zehn1109 antibody, hm:zehn1109 antibody, ACVRLK1 antibody, ALK-1 antibody, ALK1 antibody, HHT antibody, HHT2 antibody, ORW2 antibody, SKR3 antibody, TSR-I antibody, R-3 antibody, R3 antibody, SETHKIR antibody, AI115505 antibody, AI427544 antibody, Acvrlk1 antibody, Alk1 antibody, activin A receptor like type 1 antibody, activin A receptor type II-like 1 antibody, activin A receptor, type II-like 1 antibody, ACVRL1 antibody, acvrl1 antibody, Acvrl1 antibody
    背景
    ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
    分子量
    56124
    基因ID
    94
    NCBI登录号
    NP_000011, NP_001070869
    UniProt
    P37023
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