BACE1 抗体 (N-Term)
(4 references)Quick Overview for BACE1 抗体 (N-Term) (ABIN392201)
抗原
See all BACE1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 38-70, N-Term
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预测反应
- B, Rat
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This BACE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-70 amino acids from the N-terminal region of human BACE1.
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亚型
- Ig Fraction
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anti-Beta-secretase 1 (BACE1) (AA 22-501) antibody
BACE1 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 2C1 unconjugated
anti-Beta-secretase 1 (BACE1) (AA 112-324) antibodyBACE1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3C1C3 unconjugated
anti-Beta-secretase 1 (BACE1) (N-Term) antibodyBACE1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 401-501) antibodyBACE1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 22-322) antibodyBACE1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 46-155) antibodyBACE1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 72-121) antibodyBACE1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 猴, Pig, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (C-Term) antibodyBACE1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (N-Term) antibodyBACE1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Beta-secretase 1 (BACE1) (AA 170-428) antibodyBACE1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity." in: PLoS ONE, Vol. 11, Issue 11, pp. e0166415, (2017) (PubMed).
: "Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells." in: PLoS ONE, Vol. 12, Issue 3, pp. e0173240, (2017) (PubMed).
: "Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments." in: PLoS ONE, Vol. 11, Issue 3, pp. e0151147, (2016) (PubMed).
: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." in: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).
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: "An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity." in: PLoS ONE, Vol. 11, Issue 11, pp. e0166415, (2017) (PubMed).
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- BACE1 (Beta-secretase 1 (BACE1))
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别名
- BACE1
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背景
- Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
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分子量
- 55764
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基因ID
- 23621
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NCBI登录号
- NP_001193978, NP_036236, NP_620427, NP_620428, NP_620429
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UniProt
- P56817
抗原
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