DOK2 抗体 (C-Term)
Quick Overview for DOK2 抗体 (C-Term) (ABIN392072)
抗原
See all DOK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 380-412, C-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This DOK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-412 amino acids from the C-terminal region of human DOK2.
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亚型
- Ig Fraction
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anti-DOK2 (DOK2) (pTyr351) antibody
DOK2 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-DOK2 (DOK2) (AA 123-412) antibodyDOK2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DOK2 (DOK2) antibodyDOK2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DOK2 (DOK2) (C-Term) antibodyDOK2 适用: 人, Cow, Pig, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DOK2 (DOK2) (Tyr419) antibodyDOK2 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DOK2 (DOK2) antibodyDOK2 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-DOK2 (DOK2) (pTyr139) antibodyDOK2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-DOK2 (DOK2) (pTyr299) antibodyDOK2 适用: 人, 小鼠, 猴 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-DOK2 (DOK2) (AA 1-260) antibodyDOK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DOK2 (DOK2) (C-Term) antibodyDOK2 适用: 人, 小鼠, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- DOK2
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别名
- DOK2
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背景
- Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. Dok-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. Dok-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the Dok1 and Dok2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the Dok proteins serve as mediators of bcr-abl signaling. The role of Dok proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9,22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.
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分子量
- 45379
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基因ID
- 9046
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NCBI登录号
- NP_003965
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UniProt
- O60496
抗原
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