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DNMT1 抗体 (pSer714)

Name: DNMT1 抗体 (pSer714)
SKU: ABIN389901
Availability: OutOfStock

DNMT1 适用: 人 DB 宿主: 兔 Polyclonal RB19728 unconjugated

Dot blot analysis of anti-Dnmt1 Phospho-specific Pab (ABIN389901 and ABIN2839739) on nitrocellulose membrane.

1 image

产品编号 ABIN389901

发货至: 中国

Datasheet as PDF

抗原 See all DNMT1 抗体

DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
抗原表位
27

21

16

12

12

10

9

8

7

7

7

5

4

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
pSer714
适用
198

56

46

3

2

1

1

1

1

1

1
人
宿主
150

48

1

1
兔
Compatible Secondaries
克隆类型
138

62
多克隆
标记
81

16

13

11

9

9

6

6

6

6

6

6

3

3

3

3

3

2

2

2

2

2
This DNMT1 antibody is un-conjugated
应用范围
129

63

46

42

33

32

27

17

15

14

14

14

5

3

3

2

1

1

1

1

1

1
Dot Blot (DB)

预测反应

B

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This Dnmt1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S714 of human Dnmt1.

克隆位点

RB19728

亚型

Ig Fraction

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anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 21-120) antibody
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anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-270) antibody
DNMT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 881-914) antibody
DNMT1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB51461 unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibody
DNMT1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 637-650) antibody
DNMT1 适用: 人 WB, IHC, IP, ChIP 宿主: 小鼠 Monoclonal 60B1220-1 unconjugated

应用备注

DB: 1:500

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
抗原

DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

别名

Dnmt1 (DNMT1 产品)

别名

cb1075 antibody, cb983 antibody, dmnt1 antibody, fb05h01 antibody, mta antibody, wu:fb05h01 antibody, ADCADN antibody, AIM antibody, CXXC9 antibody, DNMT antibody, HSN1E antibody, MCMT antibody, DDM2 antibody, DECREASED DNA METHYLATION 2 antibody, DMT01 antibody, DMT1 antibody, DNA METHYLTRANSFERASE antibody, DNA METHYLTRANSFERASE 01 antibody, DNA METHYLTRANSFERASE 1 antibody, MET2 antibody, METHYLTRANSFERASE 2 antibody, METHYLTRANSFERASE I antibody, METI antibody, methyltransferase 1 antibody, Cxxc9 antibody, Dnmt antibody, Dnmt1o antibody, MTase antibody, Met-1 antibody, Met1 antibody, MommeD2 antibody, m.MmuI antibody, DNA methyltransferase 1 antibody, DNA (cytosine-5-)-methyltransferase 1 antibody, methyltransferase 1 antibody, DNA methyltransferase (cytosine-5) 1 antibody, DNMT1 antibody, dnmt1 antibody, Dnmt1 antibody, MET1 antibody

背景

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2Fbinding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.

分子量

183165

基因ID

1786

NCBI登录号

NP_001124295, NP_001370

UniProt

P26358

途径

SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection