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RAPTOR 抗体 (pSer863)

Cited in 1 publication. This anti-RAPTOR antibody is a 兔 多克隆 antibody detecting RAPTOR in WB, DB 和 IHC (p). Suitable for 人.
产品编号 ABIN389879
发货至: 中国
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Quick Overview for RAPTOR 抗体 (pSer863) (ABIN389879)

抗原

See all RAPTOR 抗体
RAPTOR

适用

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宿主

  • 61
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克隆类型

  • 50
  • 14
多克隆

标记

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This RAPTOR antibody is un-conjugated

应用范围

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Western Blotting (WB), Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB24817-24818
  • 抗原表位

    • 15
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    pSer863

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This Raptor Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:500. IHC-P: 1:100. DB: 1:500

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Cully, Genevet, Warne, Treins, Liu, Bastien, Baum, Tapon, Leevers, Downward: "A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1." in: Molecular and cellular biology, Vol. 30, Issue 2, pp. 481-95, (2009) (PubMed).

  • 抗原

    RAPTOR

    别名

    Raptor

    背景

    Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.

    分子量

    149038

    基因ID

    57521

    NCBI登录号

    NP_065812

    UniProt

    Q8N122

    途径

    Warburg Effect
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