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- 抗原 See all MAP4K1 抗体
- MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1))
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抗原表位
- pSer171
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MAP4K1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- M
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This MAP4K1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S171 of human MAP4K1.
- 克隆位点
- RB12751
- 亚型
- Ig Fraction
- Top Product
- Discover our top product MAP4K1 Primary Antibody
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anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (pSer171) antibody
MAP4K1 适用: 人, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (Internal Region) antibodyMAP4K1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (AA 278-377) antibodyMAP4K1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G6 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (Tyr381) antibodyMAP4K1 适用: 人 WB 宿主: 兔 Polyclonal RB58818 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (pSer171) antibodyMAP4K1 适用: 人 ELISA, DB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (N-Term) antibodyVerified MAP4K1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (N-Term) antibodyMAP4K1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (AA 231-330) antibodyMAP4K1 适用: 人 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (Internal Region) antibodyMAP4K1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) (AA 346-375) antibodyMAP4K1 适用: 人 WB 宿主: 兔 Polyclonal RB11320 unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1))
- 别名
- MAP4K1 (MAP4K1 产品)
- 别名
- HPK1 antibody, Hpk1 antibody, mHPK1 antibody, mitogen activated protein kinase kinase kinase kinase 1 antibody, mitogen-activated protein kinase kinase kinase kinase 1 antibody, Map4k1 antibody, MAP4K1 antibody
- 背景
- The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation. We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells. HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade. Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo. HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a dominant-negative MEKK1 or MKK4/SEK mutant. Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1. activation is Rac1/Cdc42-independent. These results indicate that HPK1 is a novel functional activator of the JNK/SAPK signaling pathway.
- 分子量
- 91296
- 基因ID
- 11184
- NCBI登录号
- NP_001036065, NP_009112
- UniProt
- Q92918
- 途径
- TCR Signaling, Signaling of Hepatocyte Growth Factor Receptor
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