c-MYC 抗体 (pThr58)
Quick Overview for c-MYC 抗体 (pThr58) (ABIN389723)
抗原
See all c-MYC (MYC) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pThr58
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预测反应
- X, Zf, M, Rat, B, Pig, Sh
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This MYC Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T58 of human MYC.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. DB: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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I?B kinases increase Myc protein stability and enhance progression of breast cancer cells." in: Molecular cancer, Vol. 10, pp. 53, (2011) (PubMed).
: "
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I?B kinases increase Myc protein stability and enhance progression of breast cancer cells." in: Molecular cancer, Vol. 10, pp. 53, (2011) (PubMed).
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- c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
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别名
- Myc Proto-Oncogene protein
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背景
- MYC participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia.
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分子量
- 48804
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基因ID
- 4609
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NCBI登录号
- NP_002458
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UniProt
- P01106
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途径
- p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect
抗原
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