GGPS1 抗体 (N-Term)
Quick Overview for GGPS1 抗体 (N-Term) (ABIN389055)
抗原
See all GGPS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 16-46, N-Term
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预测反应
- B, M, Rat
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This GGPS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human GGPS1.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 22059-66, (2009) (PubMed).
: "
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TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 22059-66, (2009) (PubMed).
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- GGPS1 (Geranylgeranyl Diphosphate Synthase 1 (GGPS1))
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别名
- GGPS1
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背景
- Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300-amino acid human protein contains 5 conserved domains consistent with prenyltransferases. Recombinant GGPS shows enzymatic properties associated with the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Mouse GGPS is regulated in several tissues in obesity and is induced during adipocyte differentiation. GGPS is increased 5- to 20-fold in skeletal muscle, liver, and fat of ob/ob mice. Western blot analysis detects a 2-fold overexpression of protein in muscle and fat but not in liver. Differentiation of mouse fibroblasts into adipocytes induces GGPS expression more than 20-fold.
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分子量
- 34871
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基因ID
- 9453
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NCBI登录号
- NP_001032354
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UniProt
- O95749
抗原
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