我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

FDPS 抗体 (AA 389-419)

Name: FDPS 抗体 (AA 389-419)
SKU: ABIN389054
Availability: OutOfStock

This anti-FDPS antibody is a 兔多克隆 antibody detecting FDPS in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 6+ publications.

The anti-FDPS Pab (ABIN389054 and ABIN2839263) is used in Western blot to detect FDPS in human cytokeratin liver cell lysate. (FDPS 抗体 (AA 389-419))

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with FDPS antibody (Center ) (ABIN389054 and ABIN2839263) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (FDPS 抗体 (AA 389-419))

IHC (p)

2 images

(6 references)

产品编号 ABIN389054

发货至: 中国

Datasheet as PDF

Quick Overview for FDPS 抗体 (AA 389-419) (ABIN389054)

抗原

See all FDPS 抗体

FDPS (Farnesyl Diphosphate Synthase (FDPS))

适用

人

宿主

兔

克隆类型

多克隆

标记

This FDPS antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB04786

Discover our top product FDPS Primary Antibody

抗原表位
11

7

6

3

2

2

1

1

1

1

1

1

1

1

1
AA 389-419

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the center region of human FDPS.

亚型

Ig Fraction
anti-Farnesyl Diphosphate Synthase (FDPS) antibody
FDPS 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated

anti-Farnesyl Diphosphate Synthase (FDPS) (AA 1-419) antibody
FDPS 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated

anti-Farnesyl Diphosphate Synthase (FDPS) (AA 1-419) antibody
FDPS 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Farnesyl Diphosphate Synthase (FDPS) (AA 120-419) antibody
FDPS 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Farnesyl Diphosphate Synthase (FDPS) (AA 82-112), (N-Term) antibody
FDPS 适用: 人 WB, IHC (p), IF 宿主: 兔 Polyclonal RB4783-4784 unconjugated

anti-Farnesyl Diphosphate Synthase (FDPS) antibody
FDPS 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Farnesyl Diphosphate Synthase (FDPS) (AA 1-419) antibody
FDPS 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Farnesyl Diphosphate Synthase (FDPS) antibody
FDPS 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 1049CT13-1-4 unconjugated

anti-Farnesyl Diphosphate Synthase (FDPS) (AA 1-419) antibody
FDPS 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Farnesyl Diphosphate Synthase (FDPS) (AA 320-419) antibody
FDPS 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3A6 unconjugated

应用备注

WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Sousa, Auriola, Mönkkönen, Määttä: "Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells." in: BMC cancer, Vol. 15, pp. 4, (2015) (PubMed).

Todenhöfer, Hennenlotter, Kühs, Gerber, Gakis, Vogel, Aufderklamm, Merseburger, Knapp, Stenzl, Schwentner: "Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?" in: World journal of urology, Vol. 31, Issue 2, pp. 345-50, (2013) (PubMed).

Zhang, Dai, Wang: "5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 7, pp. M111.016915, (2012) (PubMed).

Ishimoto, Tachibana, Hanano, Yamasaki, Nakamura, Kawai, Urano, Tanaka, Hamakubo, Sakai, Kodama, Doi: "Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells." in: The Biochemical journal, Vol. 429, Issue 2, pp. 347-57, (2010) (PubMed).

Räikkönen, Mönkkönen, Auriola, Mönkkönen: "Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells." in: Biochemical pharmacology, Vol. 79, Issue 5, pp. 777-83, (2010) (PubMed).

Li, Herold, Kimmel, Müller, Rincon-Orozco, Kunzmann, Herrmann: "Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 8118-24, (2009) (PubMed).
抗原

FDPS (Farnesyl Diphosphate Synthase (FDPS))

别名

FDPS

背景

The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

分子量

48275

基因ID

2224

NCBI登录号

NP_001129293, NP_001129294, NP_001229753, NP_001229754, NP_001995

UniProt

P14324

途径

Regulation of Muscle Cell Differentiation