BAP1 抗体 (AA 36-66)
(1 reference)Quick Overview for BAP1 抗体 (AA 36-66) (ABIN388948)
抗原
See all BAP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 36-66
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预测反应
- B, Zf
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This BAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-66 amino acids of human BAP1.
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亚型
- IgG
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anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 460-729) antibody
BAP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) antibodyBAP1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (pSer592) antibodyBAP1 适用: 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 1-729) antibodyBAP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 191-326) antibodyBAP1 适用: 人 ELISA, Coat 宿主: 小鼠 Monoclonal BAP1-2431 unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) antibodyBAP1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 36-66) antibodyBAP1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 460-729) antibodyBAP1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) antibodyBAP1 适用: 人 WB, ICC 宿主: 小鼠 Monoclonal BP-1 unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) antibody (Magnetic Particles)BAP1 适用: 人 IP 宿主: 小鼠 Monoclonal BP-1 Magnetic Particles
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应用备注
- IF: 1:25. WB: 1:2000. WB: 1:1000. IHC-P: 1:100. IHC-P: 1:100. FC: 1:25. IHC: 1:250
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
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有效期
- 6 months
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: "Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers." in: Journal of medical genetics, Vol. 48, Issue 12, pp. 856-9, (2011) (PubMed).
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: "Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers." in: Journal of medical genetics, Vol. 48, Issue 12, pp. 856-9, (2011) (PubMed).
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- BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))
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别名
- BAP1
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背景
- 'BRCA1-associated protein-1,' or BAP1 interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals.. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns.1 BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4.8-kb transcript expressed exclusively in testis. Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21.3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas.1 Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.1
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分子量
- 80362
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NCBI登录号
- NP_004647
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UniProt
- Q92560
抗原
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