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USP22 抗体 (C-Term)

Name: USP22 抗体 (C-Term)
SKU: ABIN388914
Availability: OutOfStock

Cited in 2+ publications. This 兔多克隆 anti-USP22 antibody (Clone RB4359) specifically detects USP22 in WB 和 IHC (p). The antibody is reactive with 人 samples.

Western blot analysis of lysates from HepG2, A549 cell line (from left to right), using USP22 Antibody (C-term) B. (USP22 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (USP22 抗体 (C-Term))

IHC (p)

2 images

(2 references)

产品编号 ABIN388914

发货至: 中国

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Quick Overview for USP22 抗体 (C-Term) (ABIN388914)

抗原

See all USP22 抗体

USP22 (Ubiquitin Specific Peptidase 22 (USP22))

适用

人

宿主

兔

克隆类型

多克隆

标记

This USP22 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB4359

Discover our top product USP22 Primary Antibody

抗原表位
15

6

5

5

4

4

1

1

1

1

1
AA 351-380, C-Term

预测反应

X, B, Zf, M

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This USP22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from the C-terminal region of human USP22.

亚型

Ig Fraction
anti-Ubiquitin Specific Peptidase 22 (USP22) antibody
USP22 适用: 人 WB 宿主: 兔 Monoclonal unconjugated

anti-Ubiquitin Specific Peptidase 22 (USP22) (Middle Region) antibody
USP22 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, Cow, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 22 (USP22) (AA 330-478) antibody
USP22 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 22 (USP22) antibody
USP22 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2475 unconjugated Recombinant Antibody

anti-Ubiquitin Specific Peptidase 22 (USP22) antibody
USP22 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2235 unconjugated Recombinant Antibody

anti-Ubiquitin Specific Peptidase 22 (USP22) (AA 121-220) antibody
USP22 适用: 人, 大鼠, 非洲爪蟾 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 22 (USP22) antibody
USP22 适用: 人 WB 宿主: 小鼠 Monoclonal 4C1 unconjugated

anti-Ubiquitin Specific Peptidase 22 (USP22) (AA 216-265) antibody
USP22 适用: 人, 大鼠, 小鼠, 非洲爪蟾, 犬, 豚鼠, 马, Cow, 兔, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 22 (USP22) (AA 72-121) antibody
USP22 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 22 (USP22) (AA 1-30), (N-Term) antibody
USP22 适用: 人 WB 宿主: 兔 Polyclonal RB4357 unconjugated

应用备注

WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Xiong, Li, He, Zeng, Zhang, He: "lncRNA HULC promotes the growth of hepatocellular carcinoma cells via stabilizing COX-2 protein." in: Biochemical and biophysical research communications, Vol. 490, Issue 3, pp. 693-699, (2017) (PubMed).

Wang, Zhu, Guo, Wang, Yang: "Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma." in: Human pathology, Vol. 46, Issue 7, pp. 1006-14, (2015) (PubMed).
抗原

USP22 (Ubiquitin Specific Peptidase 22 (USP22))

别名

USP22

背景

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

分子量

59961

基因ID

23326

NCBI登录号

NP_056091

UniProt

Q9UPT9