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PIK3C3 抗体 (AA 405-430)

This anti-PIK3C3 antibody is a 兔 多克隆 antibody detecting PIK3C3 in WB 和 IHC (p). Suitable for 人.
产品编号 ABIN388597
发货至: 中国

Quick Overview for PIK3C3 抗体 (AA 405-430) (ABIN388597)

抗原

See all PIK3C3 抗体
PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

适用

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宿主

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克隆类型

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多克隆

标记

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This PIK3C3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB11903
  • 抗原表位

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    AA 405-430

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This PI3KC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 405-430 amino acids from human PI3KC3.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. IHC-P: 1:10~50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • 抗原

    PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

    别名

    PI3KC3

    背景

    PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.

    分子量

    101549

    基因ID

    5289

    NCBI登录号

    NP_002638

    UniProt

    Q8NEB9

    途径

    AMPK Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Toll-Like Receptors Cascades, Autophagy
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