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UVRAG 抗体 (C-Term)

Name: UVRAG 抗体 (C-Term)
SKU: ABIN388586
Availability: OutOfStock

This anti-UVRAG antibody is a 兔多克隆 antibody detecting UVRAG in WB, IF 和 IHC (p). Suitable for 人和小鼠. This Primary Antibody has been cited in 7+ publications.

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hUVRAG (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (UVRAG 抗体 (C-Term))

IHC (p)

Immunofluorescence staining of Autophagy UVRAG antibody (ABIN388586 and ABIN2849984) on Methanol-fixed HeLa cells. (UVRAG 抗体 (C-Term))

Fluorescent image of cells stained with UVRAG (C-term) antibody. (UVRAG 抗体 (C-Term))

3 images

(7 references)

产品编号 ABIN388586

发货至: 中国

Quick Overview for UVRAG 抗体 (C-Term) (ABIN388586)

抗原

See all UVRAG 抗体

UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This UVRAG antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB10849

Discover our top product UVRAG Primary Antibody

抗原表位
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AA 666-699, C-Term

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-699 amino acids from the C-terminal region of human UVRAG.

亚型

Ig Fraction
anti-UV Radiation Resistance Associated Gene (UVRAG) (AA 501-699) antibody
UVRAG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-UV Radiation Resistance Associated Gene (UVRAG) (AA 375-425) antibody
UVRAG 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-UV Radiation Resistance Associated Gene (UVRAG) (AA 601-699) antibody
UVRAG 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E8 unconjugated

anti-UV Radiation Resistance Associated Gene (UVRAG) antibody
UVRAG 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-UV Radiation Resistance Associated Gene (UVRAG) antibody (HRP)
UVRAG 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal HRP

anti-UV Radiation Resistance Associated Gene (UVRAG) antibody (FITC)
UVRAG 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal FITC

anti-UV Radiation Resistance Associated Gene (UVRAG) antibody (Biotin)
UVRAG 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Biotin

anti-UV Radiation Resistance Associated Gene (UVRAG) antibody (PE)
UVRAG 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal PE

anti-UV Radiation Resistance Associated Gene (UVRAG) antibody (PerCP)
UVRAG 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal PerCP

anti-UV Radiation Resistance Associated Gene (UVRAG) antibody (APC)
UVRAG 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal APC

应用备注

IF: 1:10~50. IF: 1:200. WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Armstrong, Corazzari, Martin, Pagliarini, Falasca, Hill, Ellis, Al Sabah, Redfern, Fimia, Piacentini, Lovat: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, (2011) (PubMed).

Sun, Zhang, Fan, Wong, Ding, Chen, Zhong: "The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression." in: The Journal of biological chemistry, Vol. 286, Issue 1, pp. 185-91, (2011) (PubMed).

Neely, Green, LaFerla: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).

Sun, Westphal, Wong, Tan, Zhong: "Rubicon controls endosome maturation as a Rab7 effector." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 45, pp. 19338-43, (2010) (PubMed).

Gao, Kang, Liao, Ding, Gambotto, Watkins, Liu, Stolz, Yin: "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1371-83, (2010) (PubMed).

Sun, Fan, Chen, Ding, Chen, Zhong: "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 49, pp. 19211-6, (2008) (PubMed).

Han, Hou, Goldstein, Lu, Stolz, Yin, Rabinowich: "Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19665-77, (2008) (PubMed).
抗原

UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

别名

UVRAG

背景

UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

分子量

78151

基因ID

7405

NCBI登录号

NP_003360

UniProt

Q9P2Y5