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GABARAP 抗体 (AA 1-30)

This 兔 多克隆 antibody specifically detects GABARAP in WB, IF 和 IHC (p). It exhibits reactivity toward 人, 小鼠 和 大鼠. It has been mentioned in 4+ publications
产品编号 ABIN2849716
发货至: 中国
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Quick Overview for GABARAP 抗体 (AA 1-30) (ABIN2849716)

抗原

See all GABARAP 抗体
GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

适用

  • 97
  • 39
  • 37
  • 7
  • 6
  • 6
  • 6
  • 6
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 94
  • 10

克隆类型

  • 76
  • 28
多克隆

标记

  • 41
  • 9
  • 7
  • 6
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This GABARAP antibody is un-conjugated

应用范围

  • 69
  • 33
  • 32
  • 25
  • 24
  • 13
  • 13
  • 12
  • 6
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB11846
  • 抗原表位

    • 20
    • 15
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30

    预测反应

    B, Rb

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This GABARAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids of human GABARAP.

    亚型

    IgG
  • 应用备注

    IF: 1:25. IF: 1:25. WB: 1:1000-1 :2000. IHC-P: 1:25. IHC-P: 1:25

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Joachim, Razi, Judith, Wirth, Calamita, Encheva, Dynlacht, Snijders, OReilly, Jefferies, Tooze: "Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy." in: Current biology : CB, Vol. 27, Issue 14, pp. 2123-2136.e7, (2018) (PubMed).

    Clough, Wright, Pereira, Hirst, Johnston, Henriques, Frickel: "K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells." in: PLoS pathogens, Vol. 12, Issue 11, pp. e1006027, (2017) (PubMed).

    Egan, Chun, Vamos, Zou, Rong, Miller, Lou, Raveendra-Panickar, Yang, Sheffler, Teriete, Asara, Turk, Cosford, Shaw: "Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates." in: Molecular cell, Vol. 59, Issue 2, pp. 285-97, (2015) (PubMed).

    Orfali, ODonovan, Nyhan, Britschgi, Tschan, Cahill, Mongan, Gudas, McKenna: "Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation." in: Experimental hematology, Vol. 43, Issue 9, pp. 781-93.e2, (2015) (PubMed).

  • 抗原

    GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

    别名

    GABARAP

    背景

    Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. GABARAP is GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.

    分子量

    13918

    基因ID

    11337

    NCBI登录号

    NP_009209

    UniProt

    O95166

    途径

    Autophagy
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