LC3B 抗体 (cleaved)
(11 references)Quick Overview for LC3B 抗体 (cleaved) (ABIN388484)
抗原
See all LC3B (MAP1LC3B) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 89-122, cleaved
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预测反应
- B
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Cleaved LC3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-122 amino acids from human Cleaved LC3B.
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亚型
- Ig Fraction
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anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) antibody
MAP1LC3B 适用: 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) antibodyKO Validated MAP1LC3B 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) antibodyMAP1LC3B 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) antibodyMAP1LC3B 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5H12 unconjugated
anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) (AA 74-106) antibodyMAP1LC3B 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) (AA 1-30), (N-Term) antibodyMAP1LC3B 适用: 人, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) (N-Term) antibodyMAP1LC3B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) antibodyMAP1LC3B 适用: 人 WB, IF 宿主: 小鼠 Monoclonal unconjugated
anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) (AA 77-106) antibodyMAP1LC3B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) antibodyMAP1LC3B 适用: 人, 小鼠, 大鼠, Pig WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- IF: 1:100. IF: 1:10~50. ICC: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages." in: Journal of molecular medicine (Berlin, Germany), Vol. 95, Issue 4, pp. 405-416, (2018) (PubMed).
: "L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury." in: Neurochemical research, Vol. 42, Issue 10, pp. 2968-2981, (2018) (PubMed).
: "TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade." in: Cancer research, Vol. 76, Issue 24, pp. 7130-7139, (2017) (PubMed).
: "Mitigated NSAID-induced apoptotic and autophagic cell death with Smad7 overexpression." in: Journal of clinical biochemistry and nutrition, Vol. 60, Issue 1, pp. 55-62, (2017) (PubMed).
: "EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival." in: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Vol. 108, Issue 3, pp. 479-83, (2013) (PubMed).
: "Inhibition of the host translation shutoff response by herpes simplex virus 1 triggers nuclear envelope-derived autophagy." in: Journal of virology, Vol. 87, Issue 7, pp. 3990-7, (2013) (PubMed).
: "The gluttonous side of malignant melanoma: basic and clinical implications of macroautophagy." in: Pigment cell & melanoma research, Vol. 24, Issue 6, pp. 1116-32, (2011) (PubMed).
: "Regulation of the autophagy protein LC3 by phosphorylation." in: The Journal of cell biology, Vol. 190, Issue 4, pp. 533-9, (2010) (PubMed).
: "ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy." in: Molecular cancer, Vol. 9, pp. 95, (2010) (PubMed).
: "Regulation of the autophagic machinery in human neutrophils." in: European journal of immunology, Vol. 40, Issue 5, pp. 1461-72, (2010) (PubMed).
: "Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection." in: Nature immunology, Vol. 10, Issue 5, pp. 480-7, (2009) (PubMed).
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: "Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages." in: Journal of molecular medicine (Berlin, Germany), Vol. 95, Issue 4, pp. 405-416, (2018) (PubMed).
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- LC3B (MAP1LC3B) (Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B))
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别名
- LC3B
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背景
- Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3b is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
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分子量
- 14688
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基因ID
- 81631
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NCBI登录号
- NP_073729
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UniProt
- Q9GZQ8
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途径
- Autophagy
抗原
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