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BIM 抗体 (AA 130-165)

Name: BIM 抗体 (AA 130-165)
SKU: ABIN388101
Availability: OutOfStock

This anti-BIM antibody is a 兔多克隆 antibody detecting BIM in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 2+ publications.

The anti-Bim BH3 domain Pab (ABIN388101 and ABIN2846193) is used in Western blot to detect Bim BH3 in HL-60 cell lysate. (BIM 抗体 (AA 130-165))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (BIM 抗体 (AA 130-165))

IHC (p)

2 images

(2 references)

产品编号 ABIN388101

发货至: 中国

Quick Overview for BIM 抗体 (AA 130-165) (ABIN388101)

抗原

See all BIM (BCL2L11) 抗体

BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

适用

人

宿主

兔

克隆类型

多克隆

标记

This BIM antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB00963

Discover our top product BCL2L11 Primary Antibody

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AA 130-165

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-165 amino acids from human Bim BH3 Domain.

亚型

Ig Fraction
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 2-120) antibody
BCL2L11 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer87) antibody
BCL2L11 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-198) antibody
BCL2L11 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 134-160) antibody
BCL2L11 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22105 unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Middle Region) antibody
BCL2L11 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 51-150) antibody
BCL2L11 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer69) antibody
BCL2L11 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer69) antibody
BCL2L11 适用: 人, 小鼠, 大鼠, Cow, 绵羊 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 130-165) antibody
BCL2L11 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-100) antibody
BCL2L11 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2F10 unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Jiao, Li, Zhang, Liu, Chi: "Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells." in: Biochemical and biophysical research communications, Vol. 480, Issue 3, pp. 387-393, (2017) (PubMed).

Del Gaizo Moore, Schlis, Sallan, Armstrong, Letai: "BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia." in: Blood, Vol. 111, Issue 4, pp. 2300-9, (2008) (PubMed).
抗原

BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

别名

Bim

背景

Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.

分子量

22171

基因ID

10018

NCBI登录号

NP_001191035, NP_001191036, NP_001191037, NP_001191038, NP_001191039, NP_001191040, NP_001191041, NP_001191042, NP_006529, NP_619527, NP_619528, NP_619529, NP_619530, NP_619531, NP_61953

UniProt

O43521

途径

PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity