HDAC11 抗体 (C-Term)
Quick Overview for HDAC11 抗体 (C-Term) (ABIN387965)
抗原
See all HDAC11 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 313-345, C-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-345 amino acids from the C-terminal region of human HDAC11.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze-thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
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有效期
- 6 months
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: "The functional interactome landscape of the human histone deacetylase family." in: Molecular systems biology, Vol. 9, pp. 672, (2013) (PubMed).
: "A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression." in: Journal of virology, Vol. 83, Issue 10, pp. 4749-56, (2009) (PubMed).
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: "The functional interactome landscape of the human histone deacetylase family." in: Molecular systems biology, Vol. 9, pp. 672, (2013) (PubMed).
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- HDAC11 (Histone Deacetylase 11 (HDAC11))
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别名
- HDAC11
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背景
- HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
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分子量
- 39183
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基因ID
- 79885
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NCBI登录号
- NP_001129513, NP_079103
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UniProt
- Q96DB2
抗原
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