HDAC10 抗体 (N-Term)
(1 reference)Quick Overview for HDAC10 抗体 (N-Term) (ABIN387962)
抗原
See all HDAC10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 16-46, N-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This HDAC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human HDAC10.
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亚型
- Ig Fraction
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anti-Histone Deacetylase 10 (HDAC10) (AA 18-219) antibody
HDAC10 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 3B6B8 unconjugated
anti-Histone Deacetylase 10 (HDAC10) antibodyHDAC10 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) (N-Term) antibodyHDAC10 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) antibodyHDAC10 适用: 人 WB, IHC, FACS, IP 宿主: 小鼠 Monoclonal 4D4 unconjugated
anti-Histone Deacetylase 10 (HDAC10) antibodyHDAC10 适用: 人 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 2H6 unconjugated
anti-Histone Deacetylase 10 (HDAC10) (AA 561-669) antibodyHDAC10 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) (AA 1-669) antibodyHDAC10 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) (N-Term) antibodyHDAC10 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) (AA 10-59) antibodyHDAC10 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 10 (HDAC10) antibodyHDAC10 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression." in: Journal of virology, Vol. 83, Issue 10, pp. 4749-56, (2009) (PubMed).
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: "A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression." in: Journal of virology, Vol. 83, Issue 10, pp. 4749-56, (2009) (PubMed).
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- HDAC10 (Histone Deacetylase 10 (HDAC10))
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别名
- HDAC10
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背景
- Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93 % identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo. HDAC8 interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate to convert RUNX1 into a constitutive transcriptional repressor.
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分子量
- 71445
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基因ID
- 83933
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NCBI登录号
- NP_001152758, NP_114408
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UniProt
- Q969S8
抗原
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