我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

DNMT1 抗体 (C-Term)

Name: DNMT1 抗体 (C-Term)
SKU: ABIN387878
Availability: OutOfStock

DNMT1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB01848 unconjugated

The anti-Dnmt1 C-term Pab (ABIN387878 and ABIN2844085) is used in Western blot to detect Dnmt1 in Jurkat cell lysate.

Dnmt1 Antibody (C-term ) (ABIN387878 and ABIN2844085) flow cytometric analysis of MDA-M cells (right histogram) compared to a negative control cell (left histogram).

FACS

2 images

(2 references)

产品编号 ABIN387878

发货至: 中国

Datasheet as PDF

抗原 See all DNMT1 抗体

DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
抗原表位
27

22

16

13

12

12

10

8

8

7

7

7

6

5

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 1588-1616, C-Term
适用
203

56

46

3

2

1

1

1

1

1

1
人
宿主
155

48

1

1
兔
Compatible Secondaries
克隆类型
143

62
多克隆
标记
81

17

14

12

10

10

6

6

6

6

6

6

3

3

3

3

3

2

2

2

2

2
This DNMT1 antibody is un-conjugated
应用范围
133

68

46

42

33

32

28

17

17

15

14

14

5

3

3

2

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS)

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This Dnmt1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1588-1616 amino acids from the C-terminal region of human Dnmt1.

克隆位点

RB01848

亚型

Ig Fraction

Top Product

Discover our top product DNMT1 Primary Antibody
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-270) antibody
DNMT1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibody
DNMT1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 637-650) antibody
DNMT1 适用: 人 WB, IP, IF, ChIP, ICC, FACS, IHC (p), IHC (fro), IHC (ff) 宿主: 小鼠 Monoclonal 60B1220-1 unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibody
KO Validated DNMT1 适用: 人 WB, IHC, IP, IF, ChIP 宿主: 兔 Monoclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1448-1594) antibody
DNMT1 适用: 人, 猴 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 7C11A2 unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 21-120) antibody
DNMT1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-270) antibody
DNMT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 881-914) antibody
DNMT1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB51461 unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibody
DNMT1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 637-650) antibody
DNMT1 适用: 人 WB, IHC, IP, ChIP 宿主: 小鼠 Monoclonal 60B1220-1 unconjugated

应用备注

WB: 1:1000. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Bing, Zhu, Yu, Li, Liu, Li, Wang, Qi, Guo, Yuan, He, Liu, Liu: "Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells." in: The Journal of biological chemistry, Vol. 289, Issue 47, pp. 32639-55, (2014) (PubMed).

Li, Weyand, Goronzy: "Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells." in: Journal of leukocyte biology, Vol. 84, Issue 3, pp. 824-34, (2008) (PubMed).
抗原

DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

别名

DNMT1 (DNMT1 产品)

背景

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2Fbinding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.

分子量

183165

基因ID

1786

NCBI登录号

NP_001124295, NP_001370

UniProt

P26358

途径

SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection