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Kdm6b 抗体 (AA 954-987)

This anti-Kdm6b antibody is a 兔 多克隆 antibody detecting Kdm6b in WB. Suitable for 人 和 小鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN387864
发货至: 中国

Quick Overview for Kdm6b 抗体 (AA 954-987) (ABIN387864)

抗原

See all Kdm6b 抗体
Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

适用

  • 46
  • 24
  • 10
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  • 1
  • 1
人, 小鼠

宿主

  • 48
  • 1
  • 1

克隆类型

  • 49
  • 1
多克隆

标记

  • 33
  • 4
  • 2
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  • 1
  • 1
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  • 1
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This Kdm6b antibody is un-conjugated

应用范围

  • 37
  • 24
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  • 1
Western Blotting (WB)

克隆位点

RB10080
  • 抗原表位

    • 9
    • 7
    • 7
    • 5
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    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
    AA 954-987

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 954-987 amino acids from the Central region of mouse JMJD3.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Shaw, Martin: "Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes." in: EMBO reports, Vol. 10, Issue 8, pp. 881-6, (2009) (PubMed).

  • 抗原

    Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

    别名

    JMJD3

    背景

    Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

    分子量

    176355

    基因ID

    216850

    NCBI登录号

    NP_001017426

    UniProt

    Q5NCY0

    途径

    Warburg Effect
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