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Kdm6b 抗体 (C-Term)

Name: Kdm6b 抗体 (C-Term)
SKU: ABIN387863
Availability: OutOfStock

This anti-Kdm6b antibody is a 兔多克隆 antibody detecting Kdm6b in WB 和 IHC (p). Suitable for 小鼠. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of anti-JMJD3 C-term Pab (ABIN387863 and ABIN2844040) in untransfected 293 cells (left) and transfected 293 cells (right). (Kdm6b 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human Skeletal Muscle tissue reacted with JMJD3 Antibody (C-term) (ABIN387863 and ABIN2844040) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (Kdm6b 抗体 (C-Term))

IHC (p)

2 images

(5 references)

产品编号 ABIN387863

发货至: 中国

Quick Overview for Kdm6b 抗体 (C-Term) (ABIN387863)

抗原

See all Kdm6b 抗体

Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

适用

小鼠

宿主

兔

克隆类型

多克隆

标记

This Kdm6b antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB10081-RB10082

Discover our top product Kdm6b Primary Antibody

抗原表位
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AA 1606-1641, C-Term

预测反应

H

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1606-1641 amino acids from the C-terminal region of mouse JMJD3.

亚型

Ig Fraction
anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 265-450) antibody
Kdm6b 适用: 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1-30), (N-Term) antibody
Kdm6b 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB10077 unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1-30) antibody
Kdm6b 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1530-1682) antibody
Kdm6b 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1023-1057) antibody
Kdm6b 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB50943 unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 879-912) antibody
Kdm6b 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51280 unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (AA 1613-1662) antibody
Kdm6b 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (N-Term) antibody
Kdm6b 适用: 人, 大鼠, 犬, Cow, 马, 兔, 猴, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (Middle Region) antibody
Kdm6b 适用: 人, 小鼠, 大鼠, 犬, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) (N-Term) antibody
Kdm6b 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze-thaw cycles.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

有效期

6 months
Pham, Yu, Walline, Muthukrishnan, Blum, Kaplan: "Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 2, pp. 902-11, (2013) (PubMed).

Das, Jung, Choi, Yoon, Kim, Chai: "Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell line." in: Cell biochemistry and function, Vol. 30, Issue 3, pp. 224-32, (2012) (PubMed).

Solá, Xavier, Santos, Aranha, Morgado, Jepsen, Rodrigues: "p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation." in: PLoS ONE, Vol. 6, Issue 3, pp. e18421, (2011) (PubMed).

McLaughlin-Drubin, Crum, Münger: "Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 5, pp. 2130-5, (2011) (PubMed).

Das, Jung, Chai: "The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells." in: PLoS ONE, Vol. 5, Issue 3, pp. e9913, (2010) (PubMed).
抗原

Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

别名

JMJD3

背景

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

分子量

176355

基因ID

216850

NCBI登录号

NP_001017426

UniProt

Q5NCY0

途径

Warburg Effect