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LRRK2 抗体 (C-Term)

Cited in 2+ publications. This 小鼠 单克隆 anti-LRRK2 antibody (Clone 133AT1218) specifically detects LRRK2 in not_set. The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN387804
发货至: 中国
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Quick Overview for LRRK2 抗体 (C-Term) (ABIN387804)

抗原

See all LRRK2 抗体
LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

适用

人, 小鼠

宿主

  • 8
  • 2
小鼠

克隆类型

  • 8
  • 2
单克隆

标记

  • 10
This LRRK2 antibody is un-conjugated

应用范围

请咨询

克隆位点

133AT1218
  • 抗原表位

    • 4
    • 2
    • 2
    • 2
    • 1
    C-Term

    纯化方法

    This antibody is purified through a protein G column, followed by dialysis against PBS.

    免疫原

    This PARK8 (LRRK2) antibody was raised in mice using purified His-tagged recombinant protein comprised of the C-terminal 261 residues of LRRK2.

    亚型

    IgG1
  • 应用备注

    IHC: 1:50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Ortiz-Ortiz, Morán, Ruiz-Mesa, Niso-Santano, Bravo-SanPedro, Gómez-Sánchez, González-Polo, Fuentes: "Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells." in: Neuroscience letters, Vol. 468, Issue 2, pp. 120-4, (2009) (PubMed).

    Biskup, Moore, Rea, Lorenz-Deperieux, Coombes, Dawson, Dawson, West: "Dynamic and redundant regulation of LRRK2 and LRRK1 expression." in: BMC neuroscience, Vol. 8, pp. 102, (2008) (PubMed).

  • 抗原

    LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

    别名

    PARK8 (LRRK2)

    背景

    This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

    分子量

    286103

    基因ID

    120892

    NCBI登录号

    NP_940980

    UniProt

    Q5S007

    途径

    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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