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MSH6 抗体

This anti-MSH6 antibody is a 小鼠 单克隆 antibody detecting MSH6 in WB 和 IP. Suitable for 人, 小鼠, 大鼠 和 犬.
产品编号 ABIN379235
发货至: 中国

Quick Overview for MSH6 抗体 (ABIN379235)

抗原

See all MSH6 抗体
MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

适用

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人, 小鼠, 大鼠, 犬

宿主

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小鼠

克隆类型

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单克隆

标记

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This MSH6 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP)

克隆位点

44
  • 特异性

    MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. cross reacts with mouse, rat and dog.

    纯化方法

    Purified

    免疫原

    Synthetic human MSH6 peptide.

    Type of Immunogen: Synthetic peptide

    亚型

    IgG1
  • 应用备注

    Approved: IP, WB (1:100 - 1:500)

    说明

    Target Species of Antibody: Human

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Buffer contains: 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Do not freeze.
  • 抗原

    MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

    别名

    MSH6

    背景

    Name/Gene ID: MSH6

    Synonyms: MSH6, GTBP, HSAP, GTMBP, MutS (E. coli) homolog 6, HMSH6, Sperm-associated protein, p160, G/T mismatch-binding protein, HNPCC5, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit

    基因ID

    2956

    途径

    DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
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