MSH6 抗体
Quick Overview for MSH6 抗体 (ABIN379235)
抗原
See all MSH6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. cross reacts with mouse, rat and dog.
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纯化方法
- Purified
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免疫原
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Synthetic human MSH6 peptide.
Type of Immunogen: Synthetic peptide -
亚型
- IgG1
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应用备注
- Approved: IP, WB (1:100 - 1:500)
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说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Buffer contains: 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
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别名
- MSH6
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背景
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Name/Gene ID: MSH6
Synonyms: MSH6, GTBP, HSAP, GTMBP, MutS (E. coli) homolog 6, HMSH6, Sperm-associated protein, p160, G/T mismatch-binding protein, HNPCC5, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit -
基因ID
- 2956
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途径
- DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
抗原
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