IL2 Receptor beta 抗体 (PE)
Quick Overview for IL2 Receptor beta 抗体 (PE) (ABIN376503)
抗原
See all IL2 Receptor beta (IL2RB) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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                                            特异性
- Mouse CD122, 90-100 kDa
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                                            产品特性
- Rat Anti-Mouse CD122-PE
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                                            纯化方法
- Purified
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                                            免疫原
- Rat myeloma YB2/0 transfected with truncated IL-2Rbeta cDNA (YB2/0-mbetat-28)
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                                            亚型
- IgG2a
 
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                                            应用备注
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                        - Applications: FC - Quality tested , IP - Reported in literature
- Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE and APC conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
 
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                                            样本量
- 1 mL
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                                            限制
- 仅限研究用
 
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                                            浓度
- 0.1 mg/mL
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                                            缓冲液
- 0.1 mg in 1.0 mL of PBS/Sodium azide and a stabilizing agent
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            注意事项
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                        Do not freeze! 
 Protect conjugated products from light.
 Each reagent is stable for the period shown on the bottle label if stored as directed.
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                                            储存条件
- 4 °C
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                                            储存方法
- Store at 2-8°C
 
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    - IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))
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                                            别名
- CD122
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                                            背景
- The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the α chain which binds IL-2 with low affinity, (ii) the β chain that binds IL-2 with high affinity, and (ii) the common γ chain ( γ C ) that does not bind IL-2. The high affinity receptor complex is an α / β / γ heterotrimer with a K d of 1.3 x 10 -11 M. In mouse spleen, CD122 is expresed on approx. 30 % of CD8 + cells and all NK cells, but < 1 % of B cells and CD4 + T lymphocytes. In the thymus, its expression is confined to CD4 - CD8 + single positive and CD4 - CD8 - double negative cells. Cytoplasmic regions of the IL-2R β chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes.
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                                            途径
- JAK/STAT Signaling, Growth Factor Binding
 抗原
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