IL2 Receptor beta 抗体
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北京 101111
Quick Overview for IL2 Receptor beta 抗体 (ABIN376384)
抗原
See all IL2 Receptor beta (IL2RB) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Rat Anti-Mouse CD122-LE/AF
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特异性
- Mouse CD122, 90-100 kDa
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产品特性
- Low Endotoxin/Azide Free Anti-Mouse CD122 antibody for use in flow cytometry and immunoprecipitation assays.
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内毒素水平
- Low Endotoxin
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免疫原
- Rat myeloma YB2/0 transfected with truncated IL-2Rbeta cDNA (YB2/0-m-beta-t-28)
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate buffered saline, pH 7.4
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储存液
- Azide free
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注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
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储存条件
- 4 °C
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储存方法
- 2-8°C
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- IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))
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别名
- CD122
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背景
- The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the α chain which binds IL-2 with low affinity, (ii) the β chain that binds IL-2 with high affinity, and (ii) the common γ chain ( γ C ) that does not bind IL-2. The high affinity receptor complex is an α / β / γ heterotrimer with a K d of 1.3 x 10 -11 M. In mouse spleen, CD122 is expresed on approx. 30 % of CD8 + cells and all NK cells, but < 1 % of B cells and CD4 + T lymphocytes. In the thymus, its expression is confined to CD4 - CD8 + single positive and CD4 - CD8 - double negative cells. Cytoplasmic regions of the IL-2R β chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes.
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基因ID
- 16185
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UniProt
- P16297
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途径
- JAK/STAT Signaling, Growth Factor Binding
抗原
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