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APOC1 抗体 (C-Term)

The 山羊 多克隆 anti-APOC1 antibody is suitable to detect APOC1 in samples from 人. It has been validated for IHC (p).
产品编号 ABIN375143
发货至: 中国
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Quick Overview for APOC1 抗体 (C-Term) (ABIN375143)

抗原

See all APOC1 抗体
APOC1 (Apolipoprotein C-I (APOC1))

适用

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宿主

  • 54
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山羊

克隆类型

  • 53
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多克隆

标记

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This APOC1 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

    • 7
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    C-Term

    特异性

    This antibody recognizes Apolipoprotein CI (Apo CI).

    交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

    免疫原

    Peptide with sequence C-ETFQKVKEKLKIDS, from the C-Terminus of the protein sequence according to NP_001636.1.
  • 应用备注

    Peptide ELISA: Detection Limit Dilution: 1/8000. Immunohistochemistry on Paraffin Sections: 3-5 μg/mL. In paraffin embedded Human Liver shows spotty staining in the cytoplasm of hepatocytes.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    APOC1 (Apolipoprotein C-I (APOC1))

    别名

    Apolipoprotein C I (Apo CI)

    背景

    Apolipoprotein CI is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).Synonyms: Apo-CI, Ap °C-I, Ap °C1, Apolipoprotein C-I, Apolipoprotein C1

    基因ID

    341, 9606

    UniProt

    P02654

    途径

    Apoptosis
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