Granulin 抗体 (Internal Region)
Quick Overview for Granulin 抗体 (Internal Region) (ABIN375134)
抗原
See all Granulin (GRN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody recognizes Granulin / GRN.
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Affinity Chromatography
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免疫原
- Peptide with sequence QSKCLSKENATTD, from the internal region of the protein sequence according to NP_002078.1.
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anti-Granulin (GRN) (AA 361-585) antibody
GRN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) (AA 31-269) antibodyGRN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) antibodyGRN 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Granulin (GRN) (Center) antibodyGRN 适用: 人, 小鼠, 大鼠 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) (AA 451-550) antibodyGRN 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) (AA 44-255) antibodyGRN 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) (AA 494-593) antibodyGRN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Granulin (GRN) (AA 494-593) antibodyGRN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1F5 unconjugated
anti-Granulin (GRN) (AA 21-120) antibodyGRN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) (AA 20-310) antibodyGRN 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Peptide ELISA: 1/8000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Granulin (GRN)
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别名
- Granulins (GRN)
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背景
- Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. Involvement in disease: Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485], also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.Synonyms: GRN, Granulins, PEPI, Proepithelin
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分子量
- 63.5 kDa (NP_002078.1)
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基因ID
- 2896, 9606
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UniProt
- P28799
抗原
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