BAG4 抗体 (Internal Region)
Quick Overview for BAG4 抗体 (Internal Region) (ABIN375054)
抗原
See all BAG4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody reacts to SODD.
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纯化方法
- Affinity chromatography
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免疫原
- Peptide with sequence C-GNATSDHPNNQDQSS, from the internal region of the protein sequence
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anti-BCL2-Associated Athanogene 4 (BAG4) (AA 6-185) antibody
BAG4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 4 (BAG4) (AA 1-457) antibodyBAG4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G9 unconjugated
anti-BCL2-Associated Athanogene 4 (BAG4) (AA 1-457) antibodyBAG4 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 4 (BAG4) (C-Term) antibodyBAG4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 4 (BAG4) (Internal Region) antibodyVerified BAG4 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 4 (BAG4) (C-Term) antibodyBAG4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 4 (BAG4) (AA 1-457) antibodyBAG4 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 4 (BAG4) (C-Term) antibodyBAG4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 4 (BAG4) (AA 443-457) antibodyBAG4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 4 (BAG4) (AA 226-275) antibodyBAG4 适用: 人, 犬, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Peptide ELISA: 1/8000. Western Blot: 0.3 - 1 μg/mL.
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限制
- 仅限研究用
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浓度
- 0,5 mg/mL
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缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- BAG4 (BCL2-Associated Athanogene 4 (BAG4))
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别名
- BAG4
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背景
- Several cell surface receptors that are involved in apoptosis contain intracellular death domains and are capable of triggering apoptosis when activated by their respective ligands. Due to presence of these death domains and presence of various stimuli in the serum as well as overexpression leading to receptor oligomerization, which leads to constitutive activation of the apoptotic pathway, it has been extremely difficult to generate permanent cell lines overexpressing specific receptors in culture. However, in normal states, this death domain activity is silenced presumably due to presence of other cellular factors. Recently, a DR3 associated protein has been isolated by yeast two-hybrid interaction assays. This cDNA encoding a 457-amino acid protein has been named as SODD (Silencer of Death Domain). SODD also associates with the intracellular domains of TNF-R1, but not with those of TNF-R2, Fas, DR4, or DR5. SODD overexpression suppressed the TNF induced cell death as well as NF-kB activation. SODD may act as a negative regulatory protein that is normally associated with death domain of TNF-R1 and probably inhibit self-oligomerization properties of death domain and maintain TNF-R1 in an inactive, monomeric state. SODD (Silencer of Death Domain) is an important regulator of TNF induced apoptotic pathway. It associates with TNF-R1 to prevent constitutive activation of the signaling events downstream. It dissociates from the TNF-R1 after TNF binds TNF-R1 to allow the activation of apoptotic pathway. It is expressed ubiquitously in human tissues.Synonyms: BAG family molecular chaperone regulator 4, BAG-4, Bcl-2-associated athanogene 4, SODD, Silencer of death domains
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基因ID
- 9530, 9606
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UniProt
- O95429
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途径
- Regulation of Actin Filament Polymerization
抗原
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