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KCNJ6 抗体 (C-Term)

This anti-KCNJ6 antibody is a 山羊 多克隆 antibody detecting KCNJ6 in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN374875
发货至: 中国

Quick Overview for KCNJ6 抗体 (C-Term) (ABIN374875)

抗原

See all KCNJ6 抗体
KCNJ6 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6))

适用

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人, 小鼠, 大鼠

宿主

  • 44
  • 1
  • 1
  • 1
  • 1
山羊

克隆类型

  • 47
  • 1
多克隆

标记

  • 20
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This KCNJ6 antibody is un-conjugated

应用范围

  • 37
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Western Blotting (WB)
  • 抗原表位

    • 7
    • 5
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    • 4
    • 4
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    • 1
    C-Term

    序列

    C-SSKLNQHAEL ET

    特异性

    This antibody detects KCNJ6.

    交叉反应 (详细)

    Species reactivity (expected):Mouse, RatSpecies reactivity (tested):Human

    纯化方法

    Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

    免疫原

    Peptide from the C Terminus of the protein sequence according to NP_002231.1 Genename: KCNJ6
  • 应用备注

    Peptide ELISA: limit dilution 1: 16000. Western blot: 1-3 μg/mL. Approx 48 kDa band observed in Human Brain (Hippocampus andSubstantia Nigra) lysates (calculated MW of 48.8 kDa according to NP_002231.1). Anadditional band of unknown identity was also consistently observed at 38 kDa. This bandwas successfully blocked by incubation with the immunising peptide. We would appreciateany feedback from people in the field - have any such results been reported with otherantibodies/lysates? Have any further splice variants/modified forms been reported?
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    KCNJ6 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6))

    别名

    KCNJ6

    背景

    G-protein regulated inward-rectifier potassium channels (GIRK) are part of a superfamily of inward-rectifier K+ channels which includes seven family members. To date four GIRK subunits, designated GIRK1-4 (also designated Kir3.1-4), have been identified in mammals, and GIRK5 has been found in Xenopus oocytes. GIRK channels exist in vivo both as homotetramers and heterotetramers. GIRK channels are modulated by G-proteins, they are also modulated by phosphatidylinositol 4,5-bisphosphate, intracellular sodium, ethanol and mechanical stretch. GIRK1, 2 and 3 are highly abundant in brain. In general, neuronal GIRK channels are involved in the regulation of the excitability of neurons and may contribute to the resting potential.Synonyms: BIR1, G protein-activated inward rectifier potassium channel 2, GIRK2, Inward rectifier K(+) channel Kir3.2, KATP-2, KATP2, KCNJ6, KCNJ7, Potassium channel, inwardly rectifying subfamily J member 6

    基因ID

    3763

    NCBI登录号

    NP_002231

    UniProt

    P48051
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